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Sublingual glyceryl trinitrate given during adenosine sestamibi myocardial perfusion imaging causes apparent transient ischaemic dilation in a propensity-matched analysis.
Nucl Med Commun
February 2025
Department of Medical Imaging, The Prince Charles Hospital, Chermside.
Objectives: Administration of sublingual glyceryl trinitrate (GTN) prior to resting radiotracer injection during myocardial perfusion imaging (MPI) has been advocated to aid detection of viable myocardium and increase the extent of reversible perfusion defects. However, GTN is also known to reduce resting left ventricular volume and could thus increase the transient ischaemic dilation (TID) ratio, independently of severe or extensive coronary artery disease. We aimed to determine if GTN administration causes an increase in the TID ratio.
View Article and Find Full Text PDFPopulation Pharmacokinetics of Vancomycin in Intensive Care Patients with the Time-Varying Status of Temporary Mechanical Circulatory Support or Continuous Renal Replacement Therapy.
Infect Dis Ther
December 2024
Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, No.1, University Road, Tainan City, 701, Taiwan.
Article Synopsis
- This study evaluates how vancomycin is processed in critically ill patients, particularly those undergoing continuous renal replacement therapy (CRRT) or temporary mechanical circulatory support (tMCS).
- The research involved 25 patients and focused on how factors like serum creatinine and body weight influence drug clearance and distribution.
- It concludes that vancomycin dosing should consider both renal function and body weight, suggesting modified initial and maintenance doses for patients on CRRT, while also noting that tMCS can complicate dosing adjustments due to altered drug clearance.
Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival.
Int J Cardiol Cardiovasc Risk Prev
December 2024
Department of Cardiology and Vascular Medicine, The West German Heart and Vascular Center Essen, University Hospital Essen, 45147, Essen, Germany.
Article Synopsis
- The study focused on how smoking impacts outcomes for patients who experienced acute myocardial infarction (AMI), looking specifically at death rates over a follow-up period of about 1.14 years.
- Among 1612 AMI patients, current smokers had a higher long-term mortality rate (56% more) compared to non-smokers, while ex-smokers had similar outcomes to non-smokers.
- The findings suggest that active smoking leads to worse outcomes in terms of survival and earlier onset of heart-related issues, such as STEMI, compared to those who do not smoke.
Long-Term Interplay Between SARS-CoV-2 and Renal Impairment.
Cureus
August 2024
Department of Physiology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Introduction The SARS-CoV-2 virus causes the highly contagious coronavirus disease 2019 (COVID-19), which most commonly manifests as severe acute respiratory syndrome. The virus is part of the Coronaroviridae family, a group of viruses that can cause various diseases, such as the common cold, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). The World Health Organization (WHO) declared the outbreak of COVID-19 as a pandemic on March 11, 2020.
View Article and Find Full Text PDFTransseptal approach versus retrograde aortic approach in mapping and ablation of ventricular arrhythmias from anterolateral papillary muscles.
J Cardiovasc Electrophysiol
October 2024
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Introduction: The anterior and lateral position of the anterolateral papillary muscle (ALPM) has found to be reached with better catheter stability and less mechanical bumping via the transseptal (TS) compared to the retrograde aortic (RA) approach. The aim of this study is to compare the TS and RA approaches on mapping and ablation of ventricular arrhythmias (VAs) arising from ALPMs.
Methods: Thirty-two patients with ALPM-VAs undergoing mapping and ablation via the TS approach were included and compared with 31 patients via the RA approach within the same period.
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