AI Article Synopsis
- The study aimed to review all available evidence regarding Microsporidia infections in various hosts across Iran, emphasizing the need for a comprehensive understanding of this infection.
- A systematic review and meta-analysis of 1152 studies identified 33 eligible studies, revealing an overall prevalence of 8.18% in immunocompromised patients, with higher rates in specific regions and conditions.
- The research highlighted that Kerman and Khuzestan had the highest rates of infection, and specific genotypes of Enterocytozoon bieneusi were prevalent among patients and pigeons, underscoring the need for ongoing investigation into Microsporidia infections in diverse hosts and environments in Iran.
Article Abstract
Objective: To examine all evidence about Microsporidia infection in vertebrate/invertebrate hosts and Iranian populations distributed in different regions of the country.
Methods: All published articles up to December 2015, including descriptive and cross-sectional studies related to the prevalence and genotyping of Microsporidia infection in Iran, was considered in this systematic review. The meta-analysis was done using the random-effects model and Stats Direct statistical software. MEGA 5.05 software and maximum likelihood algorithm with Kimura 2-parameter model were used for phylogenetic analysis.
Results: Of the 1152 investigated studies, 33 eligible studies reported a prevalence of Microsporidia infection in vertebrate and invertebrate hosts. According to this systematic review, the overall prevalence rate of Microsporidia infection in immunocompromised patients in Iran was 8.18%. Furthermore, the overall prevalence rate of Microsporidia infection in immunocompromised patients with chronic diarrhoea, patients with non-diarrhoea, gastroenteritis, and patients with CD4 (<200 cells/μL) was 15.4%, 4.1%, 0.5%, and 12.9% respectively. The highest prevalence rate of human and animal Microsporidia was estimated in Kerman (29%) and Khuzestan (26.5%). The overall prevalence rate of Microsporidia infection in honeybees using the random-effects model was 40%. Furthermore, the highest prevalence rate of nosemosis was described in East Azerbaijan (48.2%). The most Microsporidia isolates from immunocompromised patients and pigeons in Iran belonged to genotypes D (n = 16; 50%) and E (n = 6; 20.6%) of Enterocytozoon bieneusi.
Conclusions: This study may be the first systematic review and meta-analysis that provides a broad outlook on the prevalence of microsporidiosis in Iran. It is necessary to investigate Microsporidia infection in vertebrate and invertebrate hosts and environmental resources in Iran.
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| http://dx.doi.org/10.1016/j.apjtm.2017.03.017 | DOI Listing |
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