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What does cancer screening have to do with tomato growing?
Clin Chem Lab Med
January 2025
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Canada.
Cancer screening is considered to be a major strategy for combatting cancer. The United States Preventive Services Task Force (USPSTF) recommends screening for five cancers, but the strength of evidence about the effectiveness of screening is limited. To gain insights into the efficacy of early detection requires prospective, blinded, placebo-controlled clinical trials with decades of follow-up and inclusion of millions of participants.
View Article and Find Full Text PDFCost Effectiveness of Colorectal Cancer Screening Strategies in Middle- and High-Income Countries: A Systematic Review.
J Gastroenterol Hepatol
January 2025
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background And Aim: Colorectal cancer (CRC) is a significant global health burden, and screening can greatly reduce CRC incidence and mortality. Previous studies investigated the economic effects of CRC screening. We performed a systematic review to provide the cost-effectiveness of CRC screening strategies across countries with different income levels.
View Article and Find Full Text PDFUrge fecal incontinence: are intramural rectal injections of botulinum toxin a long-term treatment option?
Tech Coloproctol
December 2024
Service de Gastroentérologie, Hôpital NORD, Assistance Publique Hôpitaux de Marseille; Aix-Marseille Université, Marseille, France.
Background And Aims: Unsuccessful first-line conservative treatments for managing fecal incontinence (FI) lead to considering predominantly invasive options, posing challenges in terms of cost and patient acceptance of benefit/risk ratio. Recent data from a prospective randomized study have highlighted intramural rectal botulinum toxin (BoNT/A) injection as a promising minimally invasive alternative for urge FI, demonstrating efficacy at 3 months but lacking long-term evidence. This study aimed to evaluate the sustained efficacy and injection frequency of intramural rectal BoNT/A injection in the treatment of urge FI.
View Article and Find Full Text PDFColonoscopy Remains an Important Option for Primary Screening for Colorectal Cancer.
Dig Dis Sci
December 2024
Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Article Synopsis
- - Colonoscopy is the most commonly used screening test for colorectal cancer in the U.S., with high sensitivity for detecting precancerous lesions, allowing screenings every 10 years, and possibly every 15 years for those with normal results.
- - There is substantial evidence showing colonoscopy reduces colorectal cancer incidence and mortality, supported by various studies, including comparisons with other screening methods like flexible sigmoidoscopy.
- - Advances in colonoscopy techniques, such as improved mucosal exposure methods and non-device strategies, have enhanced detection rates of precancerous lesions, along with safer resection techniques for small lesions, increasing the effectiveness of this screening option.
FIT as a Comparator for Evaluating the Effectiveness of New Non-invasive CRC Screening Test.
Dig Dis Sci
November 2024
CHU Caen Normandie, INSERM ANTICIPE U1086, Université Caen Normandie, 14000, Caen, France.
Randomized Controlled Trials (RCT) demonstrated that guaiac-based fecal occult blood test (gFOBT), sigmoidoscopy, or colonoscopy are effective at reducing colorectal cancer (CRC) risk and mortality. Even if the impact of fecal immunochemical test (FIT) has not been evaluated within population-based RCT with mortality as the outcome, the results of comparative analyses with gFOBT provide strong indirect evidence of its effectiveness. Extensive information is also available on sensitivity and specificity of FIT, compared with gFOBT.
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