AI Article Synopsis
- A new, efficient method for distinguishing between S- and R-naproxen enantiomers was developed using gold nanoclusters and bovine serum albumin, showing a stronger fluorescence quenching with S-naproxen.
- The method demonstrated specific chiral recognition due to the steric effects arising from the interactions between the serum albumin and the naproxen molecules at a pH of 7.0.
- Linear detection ranges for both enantiomers were established, along with low detection limits, suggesting the method's reliability for analyzing synthetic samples, though preprocessing to remove heavy metals is recommended for biological samples.
Article Abstract
A simple, fast and green method for chiral recognition of S- and R-naproxen has been introduced. The method was based on quenching of the fluorescence intensity of bovine serum albumin-stabilized gold nanoclusters in the presence of naproxen enantiomers. The quenching intensity in the presence of S-naproxen was higher than R-naproxen when phosphate buffer solution at pH7.0 was used. The chiral recognition occurred due to steric effect between bovine serum albumin conformation and naproxen enantiomers. Two linear determination range were established as 7.4×10-9.1×10 and 9.1×10-3.1×10molL for both enantiomers and detection limits of 7.4×10molL and 9.5×10molL were obtained for S- and R-naproxen, respectively. The developed method showed good repeatability and reproducibility for the analysis of a synthetic sample. To make the procedure applicable to biological samples, the removal of heavy metals from the sample is suggested before any analytical attempt.
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| http://dx.doi.org/10.1016/j.saa.2017.05.029 | DOI Listing |
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