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| http://dx.doi.org/10.1007/s10620-017-4617-8 | DOI Listing |
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Interaction of Th17 differentiations-related gene polymorphisms and environmental factors contributing to the disease classification, complications, and surgical risks of Crohn's disease in the Chinese Han population.
J Dig Dis
June 2024
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- - This study investigates gene-environment interactions related to Crohn's disease (CD) among the Chinese population, focusing on specific single nucleotide polymorphisms (SNPs) in T helper 17 (Th17) pathway genes.
- - Researchers analyzed data from 159 CD patients and 316 healthy controls, finding that certain SNP alleles were less common in CD patients compared to controls, with notable interactions between these genes and environmental factors like breastfeeding and sun exposure impacting disease aspects.
- - The findings enhance understanding of the genetic factors contributing to CD in Chinese populations and suggest that including these SNPs in predictive models could improve risk and outcome assessments for the disease.
The utility of capsule endoscopy in the phenotype of Crohn's disease. Data from England 2016-2021.
Arab J Gastroenterol
August 2024
Academic Unit of Gastroenterology, Sheffield Teaching Hospitals, Sheffield, UK; Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Background And Study Aims: Isolated small bowel Crohn's disease (SBCD) is reported to have a worse prognosis compared to other CD phenotypes. The aim of this study was to understand the correlation between Isolated SBCD and ileocolonic disease with blood and faecal biomarkers and also to identify differences in outcome and management between the two phenotypes.
Patients And Methods: Patients with ileocolonic or isolated small bowel Crohn's Disease (SBCD) were identified from an existing capsule endoscopy (CE) database.
Archaea influence composition of endoscopically visible ileocolonic biofilms.
Gut Microbes
June 2024
Division of Gastroenterology and Hepatology, Department of Internal Medicine 3, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- * A study analyzed the presence of archaea in stool samples from patients with IBS and ulcerative colitis (UC), finding that the absence of archaea linked to disrupted gut health and reduced microbial diversity.
- * The presence of archaea may support better GI homeostasis and fatty acid metabolism, suggesting further research is needed to explore their role in mucosal biofilms and small intestinal bacterial overgrowth.
Crohn's Disease Phenotypes and Associations With Comorbidities, Surgery Risk, Medications and Nonmedication Approaches: The MAGIC in IMAGINE Study.
Inflamm Bowel Dis
January 2025
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Background: We aimed to establish a cohort of persons with Crohn's disease (CD) enrolled from 14 Canadian centers to describe the contemporary presentation of CD in Canada.
Methods: All enrollees were at least 18 years old and underwent chart review for phenotype documentation by Montreal Classification at time of enrollment, comorbidities, inflammatory bowel disease (IBD) and other surgeries, and use IBD and other therapies.
Results: Of 2112 adults, 59% were female, and the mean age was 44.
Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn's disease patients with isolated anastomotic lesions.
Therap Adv Gastroenterol
March 2023
Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, China.
Background: Patients with isolated anastomotic lesions (iAL) are common in postoperative Crohn's disease (CD) and have heterogeneous prognosis.
Objectives: To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in CD patients with iAL.
Design: A bicenter retrospective cohort study.
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