14,15-Secopregnane-Type Glycosides with 5α:9α-Peroxy and Δ-diene Linkages from the Roots of Cynanchum stauntonii.

Molecules

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Published: May 2017

Three new 14,15-secopregnane-type glycosides, stauntosides UA, UA₁, and UA₂, were isolated from the roots of . The three compounds share the first reported and same basic structural features of 3β-hydroxy-14:16,15:20,18:20-triepoxy-5α:9α-peroxy-14,15-secopregnane-6,8(14)-diene named as stauntogenin G as the aglycones. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR and MS methods and chemical analysis. The isolation and identification of the new compounds graced the structural diversity of pregnane-type steroids from .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152625PMC
http://dx.doi.org/10.3390/molecules22060860DOI Listing

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