JD5037 (1) is a potent and selective, peripherally acting inverse agonist of the cannabinoid (CB R) receptor. Peripheral CB receptor antagonists/inverse agonists have great potential in the treatment of metabolic disorders like type 2 diabetes, obesity, and nonalcoholic steatohepatitis. We report the synthesis of octadeuterated [ H ]-JD5037 (S, S) (8) along with its (S, R) diastereomer (13) from commercially available L-valine-d starting material. The [ H ]-JD5037 compound will be used to quantitate unlabeled JD5037 during clinical ADME studies and will be used as an LC-MS/MS bioanalytical standard.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568925 | PMC |
| http://dx.doi.org/10.1002/jlcr.3521 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of rumen fluid and molasses on the nutrient composition, fermentation quality, and microflora of Caragana korshinskii Kom. silage.
Sci Rep
December 2024
College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao, 028000, China.
The aim of this experiment was to investigate the effects of rumen fluid and molasses on the nutrient composition, fermentation quality, and microflora of Caragana korshinskii Kom. The trial included four treatments: a control group (CK) without additives and experimental groups supplemented with 7% rumen fluid (R), 4% molasses (M), and 7% rumen fluid + 4% molasses (RM). 15 days and 60 days of ensiling.
View Article and Find Full Text PDFDesigning a new magnetic g-CN nanocatalyst based on Ag nanoparticles supported by β-cyclodextrin for effective reduction of nitroaromatic compounds.
Sci Rep
December 2024
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
In this study, we present the synthesis of a silver nanocomposite by utilizing a β-cyclodextrin (βCD) polymer anchored onto the surface of magnetic g-CN (referred to as g-CN-FeO/βCD-Ag). The structure and composition of the g-CN-FeO/βCD-Ag nanocomposite were thoroughly characterized using various techniques, including FT-IR, FE-SEM-EDS, TEM, TGA, XRD, ICP, and VSM. This catalytic system exhibited excellent selectivity in reducing nitro groups, even in the presence of other reactive functional groups, resulting in high yields ranging from 85 to 98%.
View Article and Find Full Text PDFA systematic review of circulating IP-10/CXCL10 in patients with Plasmodium infections in relation to disease severity.
Sci Rep
December 2024
Medical Technology Program, Faculty of Science, Nakhon Phanom University, Nakhon Phanom, Thailand.
Interferon γ-induced protein 10 kDa (IP-10) or C-X-C motif chemokine 10 (CXCL10) is produced and secreted from specific leukocytes such as neutrophils, eosinophils, and monocytes, which play key roles in the immune response to Plasmodium infections. This systematic review aimed to collate and critically appraise the current evidence on IP-10 levels in malaria patients. It provided insights into its role in malaria pathogenesis and potential as a biomarker for Plasmodium infections and disease severity.
View Article and Find Full Text PDFImmunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis.
NPJ Vaccines
December 2024
Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems (Danube University Krems), Krems, Austria.
Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccination in children and adults. We identified 20 randomized controlled trials (RCTs).
View Article and Find Full Text PDFThe relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress.
Sci Rep
December 2024
Department of Psychiatry and Behavioral Sciences and Weill Center for Neurosciences, University of California, San Francisco, CA, 94107, USA.
Telomere attrition is a hallmark of biological aging, contributing to cellular replicative senescence. However, few studies have examined the determinants of telomere attrition in vivo in humans. Mitochondrial Health Index (MHI), a composite marker integrating mitochondrial energy-transformation capacity and content, may be one important mediator of telomere attrition, as it could impact telomerase activity, a direct regulator of telomere maintenance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!