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Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.

Life Sci Space Res (Amst)

February 2025

Department of General Surgery, the 306th Hospital of PLA-Peking University Teaching Hospital, Beijing 100101, PR China; Department of General Surgery, the Ninth Medical Center of PLA General Hospital, Beijing 100101, PR China. Electronic address:

Background: Currently, there is limited research on the impact of abdominal infection on intestinal damage under microgravity conditions. Cordyceps polysaccharide (CPS), the main active ingredient of Cordyceps, has demonstrated various pharmacological effects, including anti-inflammatory, antioxidant, and immunomodulatory properties. Moxifloxacin (MXF) is a fourth-generation quinolone antibiotic that is believed to have a dual regulatory effect on immune system activation and suppression.

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Detection of Deaths Caused by Hyperkalemia.

Biomedicines

January 2025

Department of Histology and Embryology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-092 Bydgoszcz, Poland.

Under normal conditions, potassium is predominantly found within cells. The concentration gradient of sodium and potassium ions between intracellular and extracellular spaces enables signal transmission through membrane depolarization. The disruption of this transcellular process leads to elevated potassium ion levels in the extracellular space, and thus in the blood, a condition known as hyperkalemia.

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The residual concentration of pesticides and heavy metals (arsenic, mercury, selenium, lead, cadmium, and aluminum) was measured in the soil and the cattle egret (Bubulcus ibis) liver from two localities at Sharkia Governorate, Egypt. The pesticide residues have taken the following pattern: chlorpyrifos > metalaxyl > piperonyl butoxide > thiophanate-methyl, in the soil. The residual concentration of pesticides was greater in the soil at Kafr El-Ashraf village (agricultural site) than at El-Qanayat city (garbage site) during the summer season of 2021 compared with the winter season of 2022.

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Background: Atorvastatin (ATO) is an HMG-CoA reductase inhibitor used to lower blood cholesterol, but it causes renal injury in high doses. Thymoquinone (TQ), is a natural antioxidant that has been shown to protect the kidney through its anti-inflammatory, antioxidant, & antiapoptotic, effects.

Objective: The current study aimed to investigate whether posttreatment TQ could reverse ATOinduced renal injury, and the possible mechanism of action by which TQ produced such an effect.

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In recent years, bone marrow derived mesenchymal stem cells (BM-derived MSCs) have emerged as a powerful cell-based therapy for various diseases, including male infertility. Demonstrating the efficiency of BM-derived MSCs transplantation by different routes of injection to home and repair testis of busulfan-induced azoospermic rats. In the present study, rat BM-derived MSC was isolated and characterized for mesenchymal &hematopoietic markers using flow-cytometry.

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