[Embryonic cell aggregation in the loach Misgurnus fossilis L. in vivo and in vitro. The agonist of sigma opiate receptors SKF 10,047 as a regulator of the aggregation].

SKF 10,047, known as an agonist of sigma opiate receptors of the brain, specifically interacts with the surface of embryonic cells of the loach inducing clustering of concanavalin A receptors, changing rheological properties of the membrane and causing the detachment of the cultivated cells from the glass. Both, in situ and in vitro, the rate of cellular aggregation increases together with the increase in the local density of aggregates; aggregation looses its spatial homogeneity. Therefore, there is a direct relationship between destabilization of spatially homogeneous condition at the cellular and supracellular levels.