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| http://dx.doi.org/10.1093/pm/pnx119 | DOI Listing |
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Capsaicin: pharmacological applications and prospects for drug designing.
J Pharm Pharmacol
December 2024
Drugs Testing Laboratory Avam Anusandhan Kendra, Raipur, 492002, C.G., India.
Objectives: A primary objective of this review is to summarize the evidence-based pharmacological applications of capsaicin, particularly its use to manage pain and treat various health conditions. A second goal of the review is to research how recent technological advances are improving the bioavailability and therapeutic index of capsaicin, as well as the development of novel capsaicin-mimetics that are able to enhance therapeutic responses in various human diseases.
Methods: In the review, numerous human clinical trials and preclinical studies are examined to determine how effective, safe, and optimal dosages of capsaicin can be used in pain management and therapeutic applications.
Introduction: Our objective is to study the relationship between armed conflict injuries and pain and the treatments that have been applied to Ukrainian injured soldiers in our hospital.
Methods: We performed an observational study of a sample of 91 injured soldiers. The metrics we selected for the study included time from injury, length of stay, diagnosis, treatment, type and intensity of pain and questionnaires about pain and quality of life for the group of amputees.
Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review.
J Diabetes Metab Disord
December 2024
Anesthesiology Department, State University of Campinas, Campinas, Brazil.
Article Synopsis
- - The study reviewed the effectiveness of topical medications for diabetic neuropathic pain (DNP) and compared them with oral pain relief options.
- - The most promising topical treatments identified were 8% Capsaicin patches and 5% Lidocaine patches, along with evidence supporting topical clonidine, gabapentin, and amitriptyline.
- - Topical medications could be viable alternatives to oral medications for DNP, and further research is needed on combining different topical treatments for better effectiveness.
The efficacy of topical 8% capsaicin patches for the treatment of postsurgical neuropathic pain: a systematic review.
Pain Manag
December 2024
Department of Medicine, Rowan School of Osteopathic Medicine, Stratford, NJ, USA.
Objective: To investigate the benefits of topical 8% capsaicin patches for the decrease of postsurgical neuropathic pain level and area.
Methods: A systematic review with pooled analysis was conducted utilizing the PRISMA 2020 guidelines. Five commonly used databases were employed utilizing a search string made from MeSH terms and boolean operators.
Effect of Cooling Capsaicin Application Site on Reducing Burning Sensation in Neuropathic Pain Patients: A Randomized Controlled Trial.
Pain Manag Nurs
November 2024
Pain Assessment and Treatment Center, Centre Hospitalier Départemental Vendée, La Roche-sur-Yon, France.
Purpose: Treatment of localized neuropathic pain continues to represent an unmet need. The primary objective of the present study was to evaluate the efficacy of cryotherapy to reduce the burning pain induced by capsaicin (8%) patches (QUTENZA) in a neuropathic pain cohort. We also investigated subsequent neuropathic pain during an 8-week follow-up.
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