AI Article Synopsis
- Neobraclactones A-C (1-3) are newly identified compounds from the leaves of Garcinia bracteata, featuring a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one structure.
- Their structures and configurations were clarified through detailed spectroscopic analysis and ECD calculations.
- Compounds 1 and 2 demonstrated notable growth inhibition against human leukemia cell lines HL-60 and K562, with GI values ranging from 0.40 to 0.86 μM.
Article Abstract
Neobraclactones A-C (1-3), featuring an unprecedented further rearranged prenylxanthone skeleton with a unique octahydro-2H-1,3-dioxacyclopenta[c,d]inden-2-one scaffold, along with their biosynthesis-related known compound neobractatin (4), were isolated from the leaves of Garcinia bracteata. Their structures with absolute configurations were determined by extensive analyses of spectroscopic data and ECD calculations. Compounds 1 and 2 showed significant growth inhibition activities against the human leukaemia HL-60 and K562 cell lines with GI values from 0.40 to 0.86 μM.
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| http://dx.doi.org/10.1039/c7ob01007a | DOI Listing |
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