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Lanthanide Metal-Organic Framework Flowers for Proteome Profiling and Biomarker Identification in Ultratrace Biofluid Samples.
ACS Nano
January 2025
Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.
Identifying effective biomarkers has long been a persistent need for early diagnosis and targeted therapy of disease. While mass spectrometry-based label-free proteomics with trace cell has been demonstrated, deep proteomics with ultratrace human biofluid remains challenging due to low protein concentration, extremely limited patient sample volume, and substantial protein contact losses during preprocessing. Herein, we proposed and validated lanthanide metal-organic framework flowers (MOF-flowers), as effective materials, to trap and enrich protein in biofluid jointly through cation-π interaction and O-Ln coordination.
View Article and Find Full Text PDFWas Aristotle right about moral decision-making? Building a new empirical model of practical wisdom.
PLoS One
January 2025
Jubilee Centre for Character and Virtues, University of Birmingham, Birmingham, United Kingdom.
This article presents the development and validation of the Short Phronesis Measure (SPM), a novel tool to assess Aristotelian phronesis (practical wisdom). Across three studies, using large, nationally representative samples from the UK and US (demographically matched to census data), we employed a systematic and rigorous methodology to examine the structure, reliability, and validity of the SPM. In Study 1a, exploratory factor analysis identified ten distinct, internally reliable components of phronesis, challenging the traditional four-component Aristotelian model.
View Article and Find Full Text PDFIdentification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining.
Discov Oncol
January 2025
Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
Aim: This study aimed to identify the genes associated with the development of lung adenocarcinoma (LUAD) and potential therapeutic targets.
Methods: Differentially expressed genes (DEGs) were identified by self-transcriptome sequencing of tumor tissues and paracancerous tissues resected during surgery and combined with The Cancer Genome Atlas (TCGA) data to screen for the genes associated with LUAD prognosis. The expression was validated at mRNA and protein levels, and the gene knockdown was used to examine the impact and underlying mechanisms on lung cancer cells.
CTCNet: a fine-grained classification network for fluorescence images of circulating tumor cells.
Med Biol Eng Comput
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Anhui BioX-Vision Biological Technology Co., Ltd, Hefei, 230031, Anhui, China.
The identification and categorization of circulating tumor cells (CTCs) in peripheral blood are imperative for advancing cancer diagnostics and prognostics. The intricacy of various CTCs subtypes, coupled with the difficulty in developing exhaustive datasets, has impeded progress in this specialized domain. To date, no methods have been dedicated exclusively to overcoming the classification challenges of CTCs.
View Article and Find Full Text PDFBackground: (BP) is an increasingly prevalent behavior with detrimental outcomes for individuals. Three reasons for BP have been identified: Deliberate procrastination, mindless procrastination, and strategic delay. Developing an instrument to assess the reasons for BP allows better identification of patterns of behaviors and tailored interventions.
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