AI Article Synopsis
- Intraperitoneal (IP) drug delivery is a treatment for peritoneal carcinomatosis, either through chemoperfusion during surgery or repeated injections.
- The effectiveness of IP drugs is influenced by their ability to penetrate the tumor stroma, but this penetration is limited to a few millimeters.
- The text reviews tissue transport mechanisms, barriers to drug penetration, and potential interventions to enhance the delivery of drugs, which could guide future clinical trials for improving treatment outcomes in patients.
Article Abstract
Intraperitoneal (IP) drug delivery, either as an intraoperative chemoperfusion or as an adjuvant, repeated instillation, is an established treatment modality in patients with peritoneal carcinomatosis. The efficacy of IP drugs depends on its ability to penetrate the tumour stroma in order to reach their (sub)cellular target. It is known, that drug penetration after IP delivery is limited to a few millimetres. Here, we review the basic tissue transport mechanisms after IP delivery and discuss the biophysical barriers and obstacles that limit penetration distance. In addition, we review the physical and pharmaceutical interventions that have been studied in order to improve delivery of small molecular and macromolecular drugs after IP instillation. These interventions could inform the design of future clinical trials aiming at an improved efficacy of IP-based drug delivery in carcinomatosis patients.
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| http://dx.doi.org/10.1080/02656736.2017.1312563 | DOI Listing |
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