Aim: To study the evolution in the susceptibility of Enterobacter spp. in Crete, Greece from 2010 to 2015.
Methods: Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied.
Results: A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85.5%), trimethoprim/sulfamethoxazole (83.3%) and piperacillin/tazobactam (73.3%). Antibiotic resistance did not increase during the study period for most antibiotics. Lower susceptibility was observed among multidrug-resistant strains and carbapenem-nonsusceptible isolates. AmpC was the most common resistant mechanism (21%); carbapenemases (3.7%) and aminoglycoside-modifying enzymes (6.5%) were also detected.
Conclusion: A significant proportion of Enterobacter spp. was resistant to several antibiotics, most notably β-lactams.
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