The in vitro antifungal activity of a series of novel 5,5-disubstituted-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyli soxazolidines and related compounds against Trichophyton rubrum, Aspergillus fumigatus and Candida albicans was studied. The screening was performed in solid agar cultures and some structure-activity relationships involving the C-5-substitution pattern are discussed.
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