CD271 is common stem cell marker for the epidermis and dermis. We assessed a kinetic movement of epidermal and dermal CD271 cells in the wound healing process to elucidate the possible involvement with chronic skin ulcers. Epidermal CD271 cells were proliferated and migrated from 3 days after wounding. Purified epidermal CD271 cells expressed higher TGFβ2 and VEGFα transcripts than CD271 cells. Delayed wound healing was observed in the aged mice compared with young mice. During the wound healing process, the peak of dermal CD271 cell accumulation was delayed in aged mice compared with young mice. The expression levels of collagen-1, -3, -5, F4-80, EGF, FGF2, TGFβ1, and IL-1α were significantly increased in young mice compared with aged mice. Furthermore, purified dermal CD271 cells expressed higher FGF2, EGF, PDGFB, and TGFβ1 gene transcripts than CD271 cells. These results suggested that epidermal and dermal CD271 cells were closely associated with wound healing process by producing various growth factors. Epidermal and dermal CD271 cells in chronic skin ulcer patients were significantly reduced compared with healthy controls. Thus, both epidermal and dermal stem cells can play an important role in wound healing process.
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