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| http://dx.doi.org/10.1098/rsif.2017.0312 | DOI Listing |
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Interlaboratory Measurement of Adeno-Associated Virus: Comparative Quantification of Full and Empty Capsids.
Hum Gene Ther
December 2024
Prevail Therapeutics, New York, New York, USA.
Recombinant adeno-associated virus (AAV) is one of the main viral vector-based gene therapy platforms. AAV is a virus consisting of a ≈25 nm diameter capsid with a ≈4.7 kb cargo capacity.
View Article and Find Full Text PDFElevated cell-free hemoglobin: A novel early biomarker following traumatic injury.
J Trauma Acute Care Surg
December 2024
From the Department of Surgery (J.T.R.), and Blood, Heart, Lung, and Immunology Research Center (J.T.R., K.E.R.), University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Surgery (A.J.R., A.B., A.R.B., R.A.C.), University of California Davis, Sacramento, California; Department of Anesthesia and Critical Care (A.M., N.N.), Pontchaillou University Hospital of Rennes, Rennes, France; Department of Anesthesiology and Perioperative Medicine (J.D.R.), University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; and Division of Pulmonary Critical Care Medicine, Department of Medicine (K.E.R.), University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Background: Cell-free hemoglobin (CFH) and free heme are potent mediators of endotheliopathy and organ injury in sepsis, but their roles in other hemolytic pathologies are not well-defined. A prime example is trauma where early hemolysis may initiate damage and predict outcome. Here, we investigated the presence of plasma CFH, heme, and their major scavengers after traumatic injury.
View Article and Find Full Text PDFQuantification and source apportionment of atmospheric oxidation capacity in urban atmosphere by considering reactive chlorine species and photochemical loss of VOCs.
Sci Total Environ
December 2024
Department of Atmospheric Science, School of Environmental Studies, China University of Geosciences, Wuhan 430074, China; Research Centre for Complex Air Pollution of Hubei Province, Wuhan 430074, China. Electronic address:
Atmospheric oxidation capacity (AOC) reflects the potential of the atmosphere in converting primary pollutants into secondary aerosols and ozone (O). In this study, the AOC at an urban supersite in Wuhan, a megacity in central China, was quantified by considering the reactions of volatile organic compounds (VOCs) and carbon monoxide (CO) with atmospheric oxidants (OH, NO, O, and Cl). Photochemical loss of total VOCs (13.
View Article and Find Full Text PDFEMATA: a toolbox for the automatic extraction and modeling of arterial inputs for tracer kinetic analysis in [F]FDG brain studies.
EJNMMI Phys
December 2024
Department of Information Engineering, University of Padova, Padova, Italy.
Purpose: PET imaging is a pivotal tool for biomarker research aimed at personalized medicine. Leveraging the quantitative nature of PET requires knowledge of plasma radiotracer concentration. Typically, the arterial input function (AIF) is obtained through arterial cannulation, an invasive and technically demanding procedure.
View Article and Find Full Text PDFORACLE: An analytical approach for T, T, proton density, and off-resonance mapping with phase-cycled balanced steady-state free precession.
Magn Reson Med
December 2024
Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Purpose: To develop and validate a novel analytical approach simplifying , , proton density (PD), and off-resonance quantifications from phase-cycled balanced steady-state free precession (bSSFP) data. Additionally, to introduce a method to correct aliasing effects in undersampled bSSFP profiles.
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