Vulvar cancer accounts for less than 1% of malignancies in women. Verrucous carcinoma of the vulva is a rare histological variation, comprising less than 1% of vulvar cancer cases. Although it is characterized as being locally invasive, the condition is not associated with metastatic spreading. Lesions present in the form of a verrucous, ulcerated, and bleeding tumor that can reach large dimensions. This type of tumor can be mistaken for condylomata, both macroscopically and microscopically. We report the case of an 81-year-old patient with a large vulvar tumor presented for eight years, initially considered as a Buschke-Löwenstein tumor. The patient underwent radical vulvectomy with a V-Y advancement flap technique. This type of tumor should be considered by clinicians dealing with condylomatous ulcerative lesions that do not respond to the usual treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429114PMC
http://dx.doi.org/10.1590/abd1806-4841.20174929DOI Listing

Publication Analysis

Top Keywords

verrucous carcinoma
8
carcinoma vulva
8
vulvar cancer
8
type tumor
8
tumor
5
vulva diagnosis
4
diagnosis treatment
4
treatment vulvar
4
cancer accounts
4
accounts malignancies
4

Similar Publications

Background: Penile cancer is a rare malignancy treated via various surgical techniques guided by disease stage and grade with current guidelines suggesting partial or total penectomy for those with pT2 or greater. We report a case of a patient with pT2 squamous cell carcinoma (SCC) of the penis who underwent circumcision with left partial-glansectomy and resection of preputial mass with good oncological control while providing good urinary and sexual function.

Case Description: An 82-year-old male presented to the clinic due to a mass that doubled in size in an 8-month timeframe.

View Article and Find Full Text PDF

DNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia.

Pathologica

December 2024

Functional and Molecular Neuroimaging Unit, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).

Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.

View Article and Find Full Text PDF

Introduction Oral verrucous carcinoma (OVC), a low-grade variation of oral squamous cell carcinoma (OSCC), is distinguished by endophytic development and a pebbly, mammillated surface. OVC, often referred to as Ackerman's tumor, has been known to involve lymph nodes but rarely spreads to regional and distant locations; when the primary tumor grows, it frequently involves surrounding tissues. Histopathologically, it has a thicker basement membrane, many reduplications, and a large area of inflammatory infiltration that resembles OSCC.

View Article and Find Full Text PDF
Article Synopsis
  • The study focused on comparing oral lichen planus and related lesions due to their risk of becoming cancerous and the need to differentiate them from similar conditions.
  • Researchers conducted a survey among patients to collect sociodemographic and clinical data, analyzing this information using statistical tests.
  • The findings revealed distinct characteristics for each type of lesion, with lichen planus showing reticular patterns and the buccal mucosa being the most affected area, while proliferative verrucous leukoplakia was linked with significant epithelial dysplasia.
View Article and Find Full Text PDF
Article Synopsis
  • Predictive biomarkers can help identify oral leukoplakia with a higher risk of becoming cancerous, which is crucial for timely intervention.
  • Two patients presented with oral burning sensations and white lesions, leading to a diagnosis confirmed through tissue analysis.
  • The study found specific changes in microRNA expressions and antioxidant enzyme activities in patients, indicating a link between these molecular changes and the risk of malignant transformation.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!