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Localized In Vivo Prodrug Activation Using Radionuclides.
J Nucl Med
January 2025
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts;
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof of principle, we tested whether this strategy of radionuclide-induced drug engagement for release (RAiDER) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing off-target exposure to activated chemotherapy.
View Article and Find Full Text PDFExponentially Enhanced Scheme for the Heralded Qudit Greenberger-Horne-Zeilinger State in Linear Optics.
Phys Rev Lett
December 2024
Center for Quantum Information, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea and Division of Quantum Information Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea.
High-dimensional multipartite entanglement plays a crucial role in quantum information science. However, existing schemes for generating such entanglement become complex and costly as the dimension of quantum units increases. In this Letter, we overcome the limitation by proposing a significantly enhanced linear optical heralded scheme that generates the d-level N-partite Greenberger-Horne-Zeilinger (GHZ) state with single-photon sources and linear operations.
View Article and Find Full Text PDFMolecular dynamics simulation based prediction of T-cell epitopes for the production of effector molecules for liver cancer immunotherapy.
PLoS One
January 2025
School of Information and Technology, Wenzhou Business College, Wenzhou, Zhejiang, China.
Liver cancer is the sixth most frequent malignancy and the fourth major cause of deaths worldwide. The current treatments are only effective in early stages of cancer. To overcome the therapeutic challenges and exploration of immunotherapeutic options, broad spectral therapeutic vaccines could have significant impact.
View Article and Find Full Text PDFSurface molecular engineering to enable processing of sulfide solid electrolytes in humid ambient air.
Nat Commun
January 2025
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, USA.
Article Synopsis
- Sulfide solid-state electrolytes (SSEs) show great potential for all solid-state batteries due to their high ionic conductivity and flexibility, but they are sensitive to moisture, making current manufacturing methods incompatible.
- A new reversible surface modification technique using 1-undecanethiol enhances the moisture resistance of sulfide SSEs, allowing them to maintain conductivity above 1 mS cm even after 2 days of exposure to 33% relative humidity, which is significantly better than existing methods.
- This modification involves a thiol group that adheres to the SSE surface and a hydrophobic tail that repels water, paving the way for more efficient and cost-effective sulfide SSE manufacturing in battery applications.
An all integer-based spiking neural network with dynamic threshold adaptation.
Front Neurosci
December 2024
School of Integrated Circuits, Peking University, Beijing, China.
Spiking Neural Networks (SNNs) are typically regards as the third generation of neural networks due to their inherent event-driven computing capabilities and remarkable energy efficiency. However, training an SNN that possesses fast inference speed and comparable accuracy to modern artificial neural networks (ANNs) remains a considerable challenge. In this article, a sophisticated SNN modeling algorithm incorporating a novel dynamic threshold adaptation mechanism is proposed.
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