AI Article Synopsis
- The study analyzed the immunophenotypic subtypes of pediatric T-cell lymphoblastic lymphoma within a Japanese research group, involving 104 patients, with 40 providing comprehensive data.
- Various T-cell types were identified: pro-T (1 case), pre-T (9 cases), intermediate T (21 cases), and mature T (9 cases).
- The three-year event-free survival rates across these subtypes were similar, suggesting that immunophenotypic subtype did not significantly predict patient outcomes.
Article Abstract
We reviewed the immunophenotypic subtypes of pediatric T-cell lymphoblastic lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 study. Of the 104 patients, 40 patients each had sufficient data to evaluate the immunophenotypes and early T-cell precursor (ETP) subtype. Pro-T, pre-T, intermediate T, and mature T cells were observed in 1, 9, 21, and 9 cases, respectively. The 3-year event-free survival (EFS) rates of those with pro-T/pre-T, intermediate T, and mature T cells were 80.0±12.6%, 71.4±9.9%, and 88.9±10.5%, respectively (P=0.546). There were 8 and 32 cases of ETP and non-ETP subtypes, with 3-year EFS rates of 75.0±15.3% and 71.9±8.0%, respectively (P=0.828), indicating that the immunophenotypic subtype was not predictive of EFS in this study.
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| http://dx.doi.org/10.1097/MPH.0000000000000850 | DOI Listing |
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