AI Article Synopsis
Article Abstract
Due to its higher resolution, MRI in which a magnet with a field strength of 7 Tesla (7T MRI) is used, is able to image smaller abnormalities. 7T MRI is a promising tool for research into the causes of cerebral small vessel disease. Originally this technique was aimed at imaging the small perforating brain vessels and in particular at the micro-thrombi present there. Although 7T MRI has not proved effective in showing thrombi in small blood vessels, it has proved itself to be effective on other fronts. Functional measurements of the small brain vessels can be reliably determined and abnormalities of the vessel wall can be imaged. However, the most promising development is the possibility of diagnosing so-called micro-infarctions of the cortex. These extremely small infarctions are an expression of ischaemic damage in degenerating small brain vessels, which for this reason are an important marker of brain ageing.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Relaxometry and contrast-free cerebral microvascular quantification using balanced steady-state free precession MR fingerprinting.
Magn Reson Med
January 2025
Université Grenoble Alpes, INSERM, U1216, Grenoble Institute Neurosciences, GIN, Grenoble, France.
Purpose: This study proposes a novel, contrast-free Magnetic Resonance Fingerprinting (MRF) method using balanced Steady-State Free Precession (bSSFP) sequences for the quantification of cerebral blood volume (CBV), vessel radius (R), and relaxometry parameters (T , T , T *) in the brain.
Methods: The technique leverages the sensitivity of bSSFP sequences to intra-voxel frequency distributions in both transient and steady-state regimes. A dictionary-matching process is employed, using simulations of realistic mouse microvascular networks to generate the MRF dictionary.
Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET.
Methods Cell Biol
January 2025
Translational Radiomics, Luxembourg Institute of Health, Luxembourg City, Luxembourg; In-Vivo Imaging Platform, Luxembourg Institute of Health, Luxembourg City, Luxembourg.
During hypoxia, tissues are subjected to an inadequate oxygen supply, disrupting the balance needed to maintain normal function. This deficiency can occur due to reduced oxygen delivery caused by impaired blood flow or a decline in the blood's ability to carry oxygen. In tumors, hypoxia and vascularization play crucial roles, shaping their microenvironments and influencing cancer progression, response to treatment and metastatic potential.
View Article and Find Full Text PDF3-Dimensional Investigation of the Vascular Anatomy of the Triquetrum with Micro-Computed Tomography.
Ann Anat
January 2025
Department of Anatomy, Ankara University School of Medicine, Ankara, Turkey. Electronic address:
Background: This study aims to demonstrate the 3-dimensional pattern of the nutrient vessels of the triquetrum using micro-computed tomography and determine the safe region for screw applications to the bone.
Methods: Seven fresh frozen cadavers' ulnar and radial arteries were injected with Microfil MV-117. Triquetral bones were dissected and examined using micro-computed tomography.
Phoenixin-14 inhibits the formation of cerebral aneurysms in rats by downregulating the p38/NF-κB signaling pathway.
Neuropeptides
December 2024
Department of Neurology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China. Electronic address:
Cerebral aneurysms (CA) are a serious condition characterized by the bulging of a blood vessel in the brain, which can lead to rupture and life-threatening bleeding. The pathophysiology of CA involves complex processes, particularly inflammation and macrophage infiltration. Phoenixin-14 (PNX-14) is a neuropeptide with diverse biological effects, including roles in reproduction, energy homeostasis, and inflammation.
View Article and Find Full Text PDFHemodynamic Evaluation of Intra-Aortic Dual-Balloon Pump Based on Fluid-Structure Interaction.
Int J Numer Method Biomed Eng
January 2025
Department of Cardiology, First Medical Center, General Hospital of Chinese people's Liberation Army, Beijing, China.
The intra-aortic balloon pump (IABP) is a widely-used mechanical circulatory support device that enhances hemodynamics in patients with heart conditions. Although the IABP is a common clinical tool, its effectiveness in enhancing outcomes for patients with acute myocardial infarction and cardiogenic shock remains disputed. This study aimed to assess the effectiveness of intra-aortic dual-balloon pump (IADBP) and its impact on aortic hemodynamics compared with an IABP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!