AI Article Synopsis
- Bacterial methyl metabolism influences how host cells manage their mitochondria and store lipids in C. elegans.
- The research suggests that byproducts from bacteria interact with a nuclear hormone receptor in the host.
- This interaction leads to increased lipid storage, driven by the expression of a secreted protein resembling Hedgehog.
Article Abstract
Reporting in Nature Cell Biology, Lin and Wang (2017) show that bacterial methyl metabolism impacts host mitochondrial dynamics and lipid storage in C. elegans. The authors propose a model whereby bacterial metabolic products regulate a nuclear hormone receptor that promotes lipid accumulation through expression of a secreted Hedgehog-like protein.
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| http://dx.doi.org/10.1016/j.devcel.2017.05.010 | DOI Listing |
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