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Objectives: To retrospectively review our experience with artificial chords in mitral and tricuspid reconstructive surgery in children.
Methods: All consecutive paediatric (<18 years) patients who underwent mitral or tricuspid valve reconstruction with the use of artificial chords in our centre in the past 15 years were retrospectively analysed.
Results: Thirty-nine patients (age 3 days to 17 years) underwent reconstruction of the mitral (n = 27) or tricuspid (n = 12) valve using artificial chords. Mean number of chords was 3.5 ± 1.7. In 26 of 27 mitral valve patients, chords were placed on the anterior leaflet, in one on the posterior leaflet. In 10 of the 12 tricupid valve, patients chords were placed on the anterior leaflet and in 2 on the septal leaflet. All mitral patients underwent annuloplasty (10 bilateral Wooler-Kay and 17 rigid ring annuloplasty). Ten of the 12 tricuspid patients underwent annuloplasty (1 rigid ring and 9 commissural plication). Follow-up was after 8.7 ± 5.5 years. There was no early or late mortality. The actuarial freedom from reoperation rates at 1, 5 and 10 years were 95%, 91% and 81%, respectively. No reoperations occurred in the tricuspid group. In the mitral group, there were 2 early failures and 3 late reoperations due to mitral stenosis. Restricted leaflet motion probably caused by the artificial chords was seen in only 1 patient.
Conclusions: Our data show that long-term durability of mitral and tricuspid valve reconstruction using artificial chords in children is good. Despite patient growth, restricted leaflet motion by the artificial chords does not seem to form a major problem.
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http://dx.doi.org/10.1093/ejcts/ezx146 | DOI Listing |
BMC Med Inform Decis Mak
December 2024
School of Pharmacy, University of Washington, 1959 NE Pacific Street, Box 357630, Seattle, WA, 98195, USA.
Background: Interactive artificial intelligence tools such as ChatGPT have gained popularity, yet little is known about their reliability as a reference tool for healthcare-related information for healthcare providers and trainees. The objective of this study was to assess the consistency, quality, and accuracy of the responses generated by ChatGPT on healthcare-related inquiries.
Methods: A total of 18 open-ended questions including six questions in three defined clinical areas (2 each to address "what", "why", and "how", respectively) were submitted to ChatGPT v3.
J Control Release
December 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China; Department of Public Health and Medicinal Administration, Faculty of Health Sciences (FHS), University of Macau, Macau, China. Electronic address:
Rational drug development would be impossible without selecting the appropriate formulation route. However, pharmaceutical scientists often rely on limited personal experiences to perform trial-and-error tests on diverse formulation strategies. Such an inefficient screening manner not only wastes research investments but also threatens the safety of clinical volunteers and patients.
View Article and Find Full Text PDFJ Med Internet Res
December 2024
College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar.
Background: Wearable technologies have become increasingly prominent in health care. However, intricate machine learning and deep learning algorithms often lead to the development of "black box" models, which lack transparency and comprehensibility for medical professionals and end users. In this context, the integration of explainable artificial intelligence (XAI) has emerged as a crucial solution.
View Article and Find Full Text PDFSci Eng Ethics
December 2024
Institute of History and Ethics in Medicine, Department of Preclinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Ismaninger Straße 22, 81675, Munich, Germany.
Integrating artificial intelligence (AI) into critical domains such as healthcare holds immense promise. Nevertheless, significant challenges must be addressed to avoid harm, promote the well-being of individuals and societies, and ensure ethically sound and socially just technology development. Innovative approaches like Embedded Ethics, which refers to integrating ethics and social science into technology development based on interdisciplinary collaboration, are emerging to address issues of bias, transparency, misrepresentation, and more.
View Article and Find Full Text PDFPediatr Surg Int
December 2024
Department of Pediatric Surgery, Karamanoğlu Mehmetbey University, Karaman, Türkiye.
Background: We aimed to evaluate the epidemiological characteristics, risk factors and prognostic factors affecting the clinical follow-up of patients who underwent tube thoracostomy due to pneumothorax in the neonatal intensive care unit of our hospital.
Methods: In our study; 54 cases with neonatal pneumothorax underwent tube thoracostomy followed up in the neonatal intensive care unit between April 2014 and March 2023 were retrospectively analyzed.
Results: The gestational age of the cases was between 28 and 38 weeks; 24 (44.
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