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Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report.
Turk J Pediatr
December 2024
Department of Pediatric Neurology, Ankara Bilkent City Hospital, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Türkiye.
Background: Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly individuals, there is no documentation of such incidents in children as far as we are aware.
Case Presentation: This case report describes an 11-year-old girl with a history of mild intellectual disability and attention deficit hyperactivity disorder, managed with 10 mg of methylphenidate daily.
Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Am J Psychiatry
October 2024
Division of Psychotic Disorders, McLean Hospital, Belmont, MA (Moran, Shinn, Nielsen, Cohen, Erkol, Merchant, Mujica, Ongur); Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston (Moran, Skinner); Department of Psychiatry, Harvard Medical School, Boston (Moran, Shinn, Rao, Taylor, Perlis, Ongur); Department of Psychiatry, Massachusetts General Hospital, Boston (Rao, Taylor, Perlis).
Article Synopsis
- A recent study investigated the relationship between prescription amphetamines and the risk of developing psychosis or mania, finding that amphetamine use has increased in the U.S. over the past years.
- The research used case-control methods, comparing hospitalized patients with psychosis against those hospitalized for other psychiatric issues, and identified a significant link between higher doses of amphetamines and increased odds of these serious mental health outcomes.
- The findings highlight the need for cautious prescribing practices, particularly for high doses of amphetamines, along with ongoing monitoring for signs of psychosis or mania in patients.
Toxicity of New Psychoactive Substance (NPS): Threo-4-methylmethylphenidate (4-Mmph) - Prediction of toxicity using in silico methods.
Toxicol In Vitro
August 2024
Department of Regulatory and Forensic Toxicology, Institute of Medical Expertises in Łódź, ul. Aleksandrowska 67/93, 91-205 Łódź, Poland; Laboratory of Innovative Toxicological Research and Analyses, Institute of Medical Sciences, Medical College, Rzeszów University, Al. mjr. W. Kopisto 2a, 35-959 Rzeszów, Poland. Electronic address:
This study represents the first application of in silico methods to evaluate the toxicity of 4-methylphenidate (4-Mmph), a new psychoactive substance (NPS). Using advanced in silico toxicology tools, it was feasible to anticipate key aspects of 4-Mmph's toxicological profile, including acute toxicity (LD), genotoxicity, cardiotoxicity, and possible endocrine disruption. The findings indicate significant acute toxicity with variability among species, a high potential for adverse effects in the gastrointestinal system and lungs, a low genotoxic potential, a significant likelihood of skin irritation, and a notable cardiotoxicity risk associated with hERG channel inhibition.
View Article and Find Full Text PDFWHO Essential Medicines List and methylphenidate for ADHD in children and adolescents - Authors' reply.
Lancet Psychiatry
February 2024
Department of Psychiatry and Behavioral Sciences, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA.
WHO Model Lists of Essential Medicines: methylphenidate for ADHD in children and adolescents.
Lancet Psychiatry
October 2023
Department of Psychiatry and Behavioral Sciences, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA.
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