The synthesis of verrubenzospirolactone from its proposed biosynthetic precursor, capillobenzopyranol, has been shown to be chemically feasible via a simple reaction sequence. The key steps are a chemoselective furan oxidation mediated by NaClO, a stereoselective dehydration of a γ-methoxybutenolide, and an intramolecular Diels-Alder reaction.
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| http://dx.doi.org/10.1039/c7ob00868f | DOI Listing |
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