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| http://dx.doi.org/10.11604/pamj.2017.26.156.11275 | DOI Listing |
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Cyclopia: the one-eyed fetus.
Pan Afr Med J
March 2017
University of Tunis El Manar, Tunis Faculty of Medicine, 1007 Tunisia.
The calcium pump of the endoplasmic reticulum plays a role in midline signaling during early zebrafish development.
Brain Res Dev Brain Res
July 2004
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, box G-B187, Providence, RI 02912, USA.
During early vertebrate development, a signaling network is activated along the midline of the embryo. This signaling network induces the neural tube floor plate and ventral brain regions. In turn, induction of the ventral brain region is important for bilateral division of the forebrain and bilateral separation of the eyes.
View Article and Find Full Text PDFEffective targeted gene 'knockdown' in zebrafish.
Nat Genet
October 2000
Arnold and Mabel Beckman Center for Transposon Research at the University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota, USA.
The sequencing of the zebrafish genome should be completed by the end of 2002. Direct assignment of function on the basis of this information would be facilitated by the development of a rapid, targeted 'knockdown' technology in this model vertebrate. We show here that antisense, morpholino-modified oligonucleotides (morpholinos) are effective and specific translational inhibitors in zebrafish.
View Article and Find Full Text PDFMutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
Nat Genet
June 2000
The Children's Hospital of Philadelphia, Departments of Pediatrics, Genetics and Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Holoprosencephaly (HPE) is the most common structural defect of the developing forebrain in humans (1 in 250 conceptuses, 1 in 16,000 live-born infants). HPE is aetiologically heterogeneous, with both environmental and genetic causes. So far, three human HPE genes are known: SHH at chromosome region 7q36 (ref.
View Article and Find Full Text PDFcyclops encodes a nodal-related factor involved in midline signaling.
Proc Natl Acad Sci U S A
August 1998
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Ventral structures in the central nervous system are patterned by signals emanating from the underlying mesoderm as well as originating within the neuroectoderm. Mutations in the zebrafish, Danio rerio, are proving instrumental in dissecting these midline signals. The cyclops mutation leads to a loss of medial floor plate and to severe deficits in ventral forebrain development, leading to cyclopia.
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