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Childhood adversity, symptoms, and cortisol in first episode psychosis: a cross-sectional, secondary, observational analysis of a subsample of FEP patients.
Nord J Psychiatry
July 2023
Department of Health Sciences, University of Florence, Florence, Italy.
Background: Although it has been proposed that childhood adversities (CAs) may affect the hypothalamic-pituitary-adrenal (HPA) axis activity and psychotic symptoms severity, these associations have not been fully confirmed in first-episode psychosis (FEP). This study explored the association between CA, cortisol and psychotic symptoms in FEP patients.
Methods: 81 FEP patients were enrolled.
Two years after lockdown: Longitudinal trajectories of sleep disturbances and mental health over the COVID-19 pandemic, and the effects of age, gender and chronotype.
J Sleep Res
June 2023
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Article Synopsis
- The COVID-19 pandemic significantly disrupted sleep and mental health worldwide, especially during the lockdowns in Italy from 2020 to 2022.
- A study involving 1062 participants assessed changes in sleep quality, insomnia, and mental health across different demographics throughout this period, showing gradual improvements in disturbances but a decrease in overall sleep duration.
- While stress levels initially increased during the second lockdown, by April 2022, some positive trends emerged; however, ongoing monitoring is necessary to fully understand the long-term effects on sleep and mental health post-pandemic.
"First-episode psychosis: Structural covariance deficits in salience network correlate with symptoms severity".
J Psychiatr Res
April 2021
CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Trento, Italy.
Background: Patterns of coordinated variations of gray matter (GM) morphology across individuals are promising indicators of disease. However, it remains unclear if they can help characterize first-episode psychosis (FEP) and symptoms' severity.
Methods: Sixty-seven FEP and 67 matched healthy controls (HC) were assessed with structural MRI to evaluate the existence of distributed GM structural covariance patterns associated to brain areas belonging to salience network.
Walking disability measures in multiple sclerosis patients: Correlations with MRI-derived global and microstructural damage.
J Neurol Sci
October 2018
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address:
Background: The relationship between walking disability in multiple sclerosis (MS) patients and their macro- and microstructural MRI-derived measures still remains unclear.
Objective: To assess the correlations between walking disability and MRI-derived lesion, atrophy, and microstructural/axonal integrity outcomes.
Methods: Seventy-one (71) MS patients were clinically examined, the expanded timed get-up and go (ETGUG), and timed 25-foot walk (T25FW) tests were assessed.
The Partial Get-Up.
J Bodyw Mov Ther
April 2017
L.A. Sports and Spine, 10474 Santa Monica Blvd., #304, Los Angeles, CA 90025, USA. Electronic address:
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