AI Article Synopsis
- Ovarian hyperstimulation syndrome (OHSS) is a complication from fertility treatments that could adversely affect both mothers and their children, specifically regarding intellectual ability.
- A study compared 86 children born from mothers with OHSS to 172 children from mothers without OHSS during IVF, measuring their intellectual abilities using the Wechsler Intelligence Scale for Children.
- The findings indicated that children born from OHSS mothers had significantly lower IQ scores, and a higher percentage of them fell below the low IQ threshold, suggesting a potential link between prenatal estradiol exposure and reduced intellectual capacity.
Article Abstract
Background: Ovarian hyperstimulation syndrome (OHSS), a complication of ovarian stimulation, has various adverse effects on both pregnant women and their offspring. However, whether OHSS will affect intellectual ability in offspring is still unknown.
Methods: We recruited 86 Chinese children born to OHSS women and 172 children conceived with non-OHSS In Vitro Fertilization (IVF) in this cohort study. Their intellectual ability was assessed according to the Revised Chinese Version of the Wechsler Intelligence Scale for Children (C-WISC). Verbal Intelligence Quotient (VIQ), Performance Intelligence Quotient (PIQ), and Full Intelligence Quotient (FIQ) were calculated. The investigation was registered in Chinese Clinical Trial Registry (ChiCTR-SOC-16009555).
Findings: OHSS offspring scored less on C-WISC (mean (standard deviation [SD]): (VIQ=92.7 (14.7), PIQ=108.9 (13.1), FIQ=100.6 (13.4)) compared with non-OHSS IVF offspring (VIQ=100.1 (13.2), PIQ=113.7 (10.8), FIQ=107.4 (11.5)). The prevalence of low IQ (<80) children was 4.7 times higher in OHSS offspring compared with non-OHSS offspring. Maternal estradiol level on hCG administration day was negatively associated with FIQ in offspring.
Interpretation: OHSS offspring displayed reduced intellectual ability. Prenatal estradiol exposure might be involved in underlying mechanism.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478241 | PMC |
| http://dx.doi.org/10.1016/j.ebiom.2017.05.020 | DOI Listing |
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