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Predicting treatment outcome using kinome activity profiling in HER2+ breast cancer biopsies.
iScience
June 2024
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, 3584 CH Utrecht, the Netherlands.
In this study, we measured the kinase activity profiles of 32 pre-treatment tumor biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels, to identify potential mechanisms of resistance and to predict treatment success of HER2-targeted therapy combined with chemotherapy. Indeed, our system-wide kinase activity analysis allowed us to link kinase activity to treatment response.
View Article and Find Full Text PDFHepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study.
Cardiovasc Diabetol
March 2024
Division of Human Nutrition and Health, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Background: Tissue-specific insulin resistance (IR) predominantly in muscle (muscle IR) or liver (liver IR) has previously been linked to distinct fasting metabolite profiles, but postprandial metabolite profiles have not been investigated in tissue-specific IR yet. Given the importance of postprandial metabolic impairments in the pathophysiology of cardiometabolic diseases, we compared postprandial plasma metabolite profiles in response to a high-fat mixed meal between individuals with predominant muscle IR or liver IR.
Methods: This cross-sectional study included data from 214 women and men with BMI 25-40 kg/m, aged 40-75 years, and with predominant muscle IR or liver IR.
Oil-water interface and emulsion stabilising properties of rapeseed proteins napin and cruciferin studied by nonlinear surface rheology.
J Colloid Interface Sci
May 2024
Laboratory of Physics and Physical Chemistry of Foods, Wageningen University, Bornse Weilanden 9, 6708WG Wageningen, the Netherlands. Electronic address:
Article Synopsis
- The study investigates two protein families in rapeseed, cruciferins and napins, and how their structural differences affect oil-water interface stabilization.
- Through experiments using techniques like SEC and DSC, the researchers evaluated protein properties and the mechanical behavior of oil-water interfaces, as well as the emulsifying capabilities of these proteins in different mixtures.
- Findings reveal that cruciferins create more stable oil droplets than napins, which leads to a higher resistance against coalescence, highlighting the distinct roles each protein plays in emulsions.
Innovative strategies for measuring kinase activity to accelerate the next wave of novel kinase inhibitors.
Drug Discov Today
March 2024
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH, The Netherlands; Netherlands Proteomics Center, Padualaan 8, Utrecht 3584 CH, The Netherlands. Electronic address:
The development of protein kinase inhibitors (PKIs) has gained significance owing to their therapeutic potential for diseases like cancer. In addition, there has been a rise in refining kinase activity assays, each possessing unique biological and analytical characteristics crucial for PKI development. However, the PKI development pipeline experiences high attrition rates and approved PKIs exhibit unexploited potential because of variable patient responses.
View Article and Find Full Text PDFExploring the potential of Bacillus subtilis as cell factory for food ingredients and special chemicals.
Microb Cell Fact
September 2023
Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1098 XH, The Netherlands.
Background: Bacillus subtilis has been established as model microorganism for fundamental research in the laboratory on protein production/secretion and sporulation and as model bacterium for controlling spoilage in the food industry. It has also been used for production of (commercial) enzymes and several secondary metabolites such as vitamins. However, this doesn't fully reflect the potential of B.
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