The synthesis of chiral tetrahydrofurans and pyrrolidines starting from 1,2-diols or β-amino alcohols, respectively, by visible-light-mediated deoxygenation is described. Easily accessible monoallylated/propargylated substrates were activated either as inexpensive ethyl oxalates or as recyclable 3,5-bis(trifluoromethyl)benzoates to generate alkyl radicals suitable for 5--/5-- cyclizations under visible-light irradiation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412674 | PMC |
| http://dx.doi.org/10.1002/ejoc.201700014 | DOI Listing |
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