AI Article Synopsis
- The study highlights the lack of understanding regarding how extracellular vesicles (EVs) contribute to the molecular differences in glioblastoma (GBM) subtypes.
- Researchers analyzed the microRNA expression and secretion among different subpopulations of GBM stem-like cells (GSCs) to uncover the complex dynamics within tumors.
- The findings suggest that the exchange of microRNAs among these cells increases the heterogeneity of GSCs, leading to varied microRNA profiles in different GBM subtypes.
Article Abstract
Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470095 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2017.04.024 | DOI Listing |
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