Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy.
Free Radic Biol Med
March 2025
Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. Electronic address:
Auranofin (AF) is a gold-based compound and it has been used in the treatment of rheumatoid arthritis for over four decades. Recently, it has been demonstrated to show significant antitumor activity across various cancer types and is being repurposed as an anticancer drug. However, the precise mechanisms underlying its antitumor effects, particularly its binding targets, remain poorly understood.
View Article and Find Full Text PDFA sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2/HO-1/NQO1 signaling pathway.
Pharmacol Res
March 2025
State Key Laboratory of Traditional Chinese Medicine Syndrome /The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong Province 510405, China; State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Taipa, Macao, PR China; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong-Macao In-Depth Cooperation Zone in Hengqin 519000, China. Electronic address:
Bone destruction in rheumatoid arthritis (RA) leads to significant disability, yet effective treatments are limited. Sinomenine (Sino) demonstrates anti-arthritic and bone-protective effects but requires high doses. In this study, we developed a Sino derivative, SINX, and evaluated its efficacy in RA.
View Article and Find Full Text PDFFCGR1A(CD64) expression on monocyte subsets and FIL1Z(IL-37) serum level as biomarkers of rheumatoid arthritis activity: A case controlled study and in silico analysis.
Pathol Res Pract
March 2025
Biochemistry Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.
Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Chronic joint inflammation and bone destruction were shown to be caused by expanded monocytes in RA affected individuals. Interleukin-37 which known as FIL1Z(IL-37) is a well-known anti-inflammatory cytokine that plays a negative regulatory role of inflammation in RA.
View Article and Find Full Text PDFDUOX1 inhibits the progression of rheumatoid arthritis by regulating the NF-κB pathway in vitro.
Allergol Immunopathol (Madr)
March 2025
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Wannan Medical College, Wuhu,Anhui,241000, China;
Background: This study investigates the role of dual oxidase 2 (DUOX1) in fibroblast-like synoviocytes associated with rheumatoid arthritis (RA) and to elucidate its potential mechanism of action.
Method: The anti-inflammatory effects of DUOX1 were assessed using IL-1β (interleukin-1 beta)-stimulated synovial fibroblasts (MH7A). Cell viability and migration were evaluated using the Cell Counting Kit-8 and Transwell assays, respectively.
Association between C-reactive protein and hemoglobin in US rheumatoid arthritis patients based on NHANES data analysis.
Sci Rep
March 2025
Department of Traditional Chinese Medicine, The General Hospital of Western Theater Command, No. 270 Tianhui Road, Chengdu, 610083, Sichuan, China.
The poor prognosis of rheumatoid arthritis (RA) and its potential for complications highlight the importance of understanding factors that are associated with incidence and mortality rates. The inclusion criteria of this study were RA-related data from 1999 to 2018 in the National Health and Nutrition Examination Survey (NHANES) dataset. Based on certain screening criteria, a total of 610 subjects were recruited.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!