Mechano-electric coupling, heterogeneity in repolarization and the electrocardiographic T-wave.

Stretch influences repolarization by mechano-electric coupling (MEC) and contributes to arrhythmogenesis. Although there is an abundance of research on electrophysiological effects of MEC, it is still unclear how MEC translates to the ECG. We aim to provide an overview of the MEC research focused on the ECG and the underlying changes in electrophysiology. In addition, we present new data on the effect of left ventricular pressure on the electrocardiographic T-wave. We show that an increase in left ventricular pressure leads to prolonged QT-intervals with increased amplitudes of the STT-segment. This corresponds to a prolongation in repolarization and an increased interventricular dispersion of repolarization. MEC is dependent on timing, intensity and modality of stretch and these three factors should be taken into account to analyse the effects of MEC on the heart and on the ECG. In addition, the deformation of the heart itself should be considered, since it influences the amplitude of the STT-segment. Because the electrocardiographic T-wave represents heterogeneity in repolarization, left ventricular pressure increases may have significant influence on the inducibility of (re-entrant) arrhythmias.