AI Article Synopsis
- The study focuses on testing new nanoparticles and nanogels that carry amoxicillin to effectively target and treat H. pylori infections.
- Researchers created specialized nanogels using a mixture of fucoidan and chitosan to aim the medication precisely at infected gastric cells.
- The results showed that these nanogels could stick to H. pylori and release amoxicillin in response to pH changes, suggesting they could minimize side effects and be useful for future medical applications.
Article Abstract
Aim: This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection.
Materials & Methods: Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells.
Results: The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells.
Conclusion: These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.
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| http://dx.doi.org/10.2217/nnm-2017-0055 | DOI Listing |
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Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection.
Nanomedicine (Lond)
June 2017
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Article Synopsis
- The study focuses on testing new nanoparticles and nanogels that carry amoxicillin to effectively target and treat H. pylori infections.
- Researchers created specialized nanogels using a mixture of fucoidan and chitosan to aim the medication precisely at infected gastric cells.
- The results showed that these nanogels could stick to H. pylori and release amoxicillin in response to pH changes, suggesting they could minimize side effects and be useful for future medical applications.
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