Brain tissues from 38 patients with a clinical suspicion of encephalitis or encephalopathy were examined by two immunoenzymatic techniques for the detection of arboviral antigen. Group B arboviral antigen was identified in 23 of these tissues. This simple method could be used for the diagnosis of the causal agent of encephalitis.
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Article Synopsis
- Dengue virus (DENV) is a significant global health issue, with severe cases potentially worsened by antibodies that can enhance infection rather than neutralize it.
- Researchers are exploring the possibility of targeting DENV-infected cells for immune clearance to avoid antibody-dependent enhancement (ADE).
- This study found that DENV structural proteins are present on infected cell surfaces and can be recognized by immune antibodies, which may facilitate the clearance of infected cells without enriching viral material in certain immune cells.
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