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Comparative Efficacy and Long-Term Outcomes of Beta-Blockers Alone or in Combination With Angiotensin-Converting Enzyme (ACE) Inhibitors in Chronic Heart Failure: A Systematic Review.
Cureus
November 2024
Internal Medicine, Nishtar Medical University, Multan, PAK.
This systematic review provides a comprehensive comparison of beta-blockers and angiotensin-converting enzyme (ACE) inhibitors in the management of chronic heart failure (CHF), with a focus on their long-term efficacy and safety profiles. By synthesizing evidence from randomized controlled trials (RCTs) and clinical studies, the review highlights the significant benefits of both drug classes in reducing mortality and hospital readmissions, and improving patient outcomes. Beta-blockers, such as bisoprolol and carvedilol, demonstrated superior efficacy in reducing sudden cardiac death, particularly in patients with heart failure with reduced ejection fraction (HFrEF).
View Article and Find Full Text PDFSerum symmetric dimethylarginine concentrations in enalapril- or telmisartan-treated dogs with proteinuric chronic kidney disease.
Front Vet Sci
December 2024
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Introduction: Renin-angiotensin-aldosterone system inhibition (RAASi) reduces intraglomerular pressure and is a standard therapy for dogs with proteinuric chronic kidney disease (CKD). RAASi can acutely decrease glomerular filtration rate (GFR); however, its effects on the marker of GFR serum symmetric dimethylarginine (SDMA) concentration in dogs have not been specifically evaluated. The objective of this study was to evaluate changes, relative to pretreatment values, in serum SDMA concentrations in dogs with proteinuric CKD receiving RAASi therapy.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates factors affecting the long-term pulse pressure of hypertensive patients at Assosa General Hospital in Ethiopia over a two-year period.
- Among the 325 patients, key factors influencing pulse pressure included age, residence, family history of hypertension, diabetes, chronic kidney disease, smoking status, and the stage of hypertension.
- Findings suggest that while certain treatments and longer follow-up time help reduce pulse pressure, other risk factors need to be managed to improve health outcomes in hypertensive patients.
Combined Therapy with Azathioprine, Prednisone, and Enalapril in Children with IgAN and IgAVN.
J Clin Med
December 2024
Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
: The aim of this study was to evaluate the efficacy of 1-year treatment in children with IgAN and IgAVN using azathioprine, prednisone, and enalapril (AZA+PRED+E) combined with a control kidney biopsy. : This study consists of 68 children diagnosed via kidney biopsy with Oxford classification. The study group included 36 children (15 IgAN, 21 IgAVN) treated with AZA+PRED+E (according to the protocol with a control kidney biopsy); and the control group included 32 children (21 IgAN, 11 IgAVN) who were treated with enalapril alone during one year after kidney biopsy.
View Article and Find Full Text PDFThe Effects of Different Treatments on Serum Trace Element Levels in Dogs with Heart Failure.
Animals (Basel)
November 2024
Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey.
Article Synopsis
- * A total of 107 dogs were divided into treatment groups, and the serum levels of several trace elements, including magnesium and iron, were measured using advanced spectroscopy techniques.
- * Results showed significant changes in serum magnesium and iron levels with longer treatment durations, indicating that the use of these heart medications could affect trace element levels in dogs with heart failure.
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