Experiments were performed on isolated hearts of adult (8-10 months old) and aged (24-26 months old) rats perfused with the Krebs-Henseleit solution according to the method of Langendorf. It was demonstrated that when oxygen supply was insufficient (pO2 of the perfusion solution-100 mm Hg), the chronotropic reaction of the heart to the stimulation of alpha- and beta-adrenergic receptors with phenylephrine hydrochloride (5 x 10(-7)--10(-5) M) and isoprenaline (10(-9)--10(-6) M), respectively, increased in adult rats and decreased in aged animals. Positive inotropic effects of adrenoagonists in hypoxic hearts diminished but their values as well as those at adequate oxygenation (pO2 = 600 mm Hg) were higher in aged rats. Stimulation of adrenoreceptors in the case of inadequate oxygenation increased hypoxic myocardial contracture, the increase being greater in adult rats.
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