AI Article Synopsis
- Vascular-targeted photodynamic therapy is effective in treating port wine stains.
- A new model has been developed to understand how blood flow, oxygen, and light interact during the treatment.
- The findings suggest that synchronizing light pulses with heartbeats enhances oxygen accumulation and temperature control, leading to potentially better treatment outcomes compared to constant light.
Article Abstract
Vascular-targeted photodynamic therapy has shown efficiency in treating port wine stains. A dynamic model that incorporates blood flow, kinetic diffusion, oxygen and photosensitizer consumption and reaction, and light modulation is proposed to reveal the interactions among light, photosensitizer, and oxygen. Simulation results show that pulse light modulation synchronized with heartbeats hold the advantage of increased singlet oxygen accumulation, higher oxygen concentration and lower temperature. Meanwhile, constant light treatment is advantageous in terms of higher temperature, lower total oxygen concentration and singlet oxygen accumulation. Therefore, the optimized treatment protocol may involve a balance among the phototoxicity, hypoxia, and photothermolysis.
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| http://dx.doi.org/10.1080/10255842.2017.1331344 | DOI Listing |
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