Electrospun nanofibers represent a novel class of materials that show great potential in many biomedical applications including biosensing, regenerative medicine, tissue engineering, drug delivery and wound healing. In this work, we review recent advances in electrospun nanofibers for wound healing. This article begins with a brief introduction on the wound, and then discusses the unique features of electrospun nanofibers critical for wound healing. It further highlights recent studies that have used electrospun nanofibers for wound healing applications and devices, including sutures, multifunctional dressings, dermal substitutes, engineered epidermis and full-thickness skin regeneration. Finally, we finish with conclusions and future perspective in this field.
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http://dx.doi.org/10.2217/nnm-2017-0017 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, PO Box: 91895-157-356, Iran. Electronic address:
The objective of this research is to develop a natural macromolecules-based smart double-layer film using carboxymethyl cellulose (CMC) film containing pomegranate peel anthocyanins (PPA) and cellulose acetate nanofibers (CANFs) with Artemisia sieberi Besser essential oil-loaded nanostructured lipid carriers (ABNLCs). Based on the performance as a color indicator, and other studied properties, the CMC/PPA 8 % film was selected as the optimized film. The double-layer film was constructed by electrospinning the CANFs containing ABNLCs on the optimized CMC film.
View Article and Find Full Text PDFBiofabrication
January 2025
College of Textiles & Clothing, Qingdao University, 308 Ningxia Road, Qingdao, Qingdao, Shandong, 266071, CHINA.
The design and development of advanced surgical sutures with appropriate structure and abundant bio-functions are urgently required for the chronic wound closure and treatment. In this study, an integrated technique routine combining modified electrospinning with hot stretching process was proposed and implemented to fabricate poly(L-lactic acid) (PLLA) nanofiber sutures, and the Salvia miltiorrhiza Bunge-Radix Puerariae herbal compound (SRHC) was encapsulated into PLLA nanofibers during the electrospinning process to enrich the biofunction of as-generated sutures. All the PLLA sutures loading without or with SRHC were found to exhibit bead-free and highly-aligned nanofiber structure.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
January 2025
Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi 214000, China. Electronic address:
During surgical procedures, skin and soft tissue wounds are often infected by resistant strains of gram-positive bacteria and gram-negative bacteria, resulting in serious obstacles to the healing of these wounds. Commercially available dressings for such wounds are still insufficient to combat resistant infections. Here, we designed vancomycin and epigallocatechin gallate (EGCG) loaded poly(vinyl)-pyrrolidone-gelatine nanofiber's membrane dressing for potential synergistic efficiency against infected post-surgical wounds.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Division of Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, 24143 Kiel, Germany; Kiel Nano, Surface and Interface Science (KiNSIS), Kiel University, 24118 Kiel, Germany. Electronic address:
Curcumin, a hydrophobic drug derived from the rhizome of Curcuma longa, exhibits significant bioactive properties, including antioxidant and antimicrobial potential. However, its poor water solubility and rapid degradation limit its practical applications. This study presents a novel design of electrospun nanofibers using Curcumin/hydroxypropyl-β-cyclodextrin inclusion complex (HP-β-CD-IC) combined with pullulan to enhance thermal stability and controlled release.
View Article and Find Full Text PDFCurr Res Food Sci
December 2024
Department of Food Nanotechnology, Research Institute of Food Science and Technology (RIFST), Mashhad, Iran.
To improve the stability of D-limonene, a protective barrier is essential to prevent degradation and maintain its integrity. Therefore, the potential of using seed gum (LPSG) as a novel source for creating electrospun nanofibers for D-limonene encapsulation was investigated by varying LPSG concentrations (0.25%, 0.
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