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In the experiments on dogs, the role of a pharmacological circulatory hypoxia in the mechanism of radioprotective effect of indraline and mexamine was studied. Angiography revealed 20-40% vasoconstriction of major arteries of legs of animals, of pelvis and abdomen caused by mexamine (10 mg/kg) and the absence of a significant effect of indraline. Disruption of a regional blood circulation in the marrow and spleen (40-50% and 70-80%, respectively) was caused by indraline to the same extent as by mexamine.
View Article and Find Full Text PDFFatty acid spectrum of phospholipids and free cholesterol level in the myocardium, liver and erythrocytes were studied in dogs with the experimental lung-heart insufficiency (LHI). The content of polyunsaturated fatty acids of phospholipids in erythrocytes from peripheric blood and in free cholesterol level (2-3 times) in myocardium, liver and erythrocytes of dogs under investigated conditions decreased. It is shown that pharmacotherapy with alpha-adrenoblockers (thropaphen and prasozin) has led to the normalization of disturbances of the erythrocytic lipid complex and had caused inhibition of peroxidase reactions in the myocardium and liver of the dogs with LHI.
View Article and Find Full Text PDF[Change in the functional activity of the blood complement system after administration of adrenaline to animals].
Patol Fiziol Eksp Ter
January 1996
Epinephrine given to non-inbred male albino rats in a pharmacological dose of 1 mg/kg was studied for effects on their serum complement. Following 5 min of its administration, the complement activity both of blood overall and individual parameters reduced by 0.4-0.
View Article and Find Full Text PDFThe ischemia-induced decrease of the hematocrit index was the greatest in precapillaries and smallest capillaries. Significant oscillations of the index occurred in reperfusion. Tropafen decreased the index.
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