Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-4899-5037-6_20 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Delving into Matrix Metalloproteinase-1 (MMP-1) and its Significance in Periodontal Diseases.
J Pharm Bioallied Sci
April 2024
Department of Clinical Sciences, College of Dentistry, Centre of Medical and Bio-Allied Health Sciences and Research, Ajman University, Ajman, UAE.
Matrix metalloproteinase-1 (MMP-1) plays a pivotal role in the pathogenesis of periodontal diseases, particularly periodontitis, by virtue of its collagenolytic activity targeting collagen type I, the primary component of periodontal tissues. This review abstract elucidates the intricate involvement of MMP-1 in periodontal tissue homeostasis and its dysregulation in disease states. Elevated MMP-1 levels, observed in gingival tissues and crevicular fluid of individuals with periodontitis, correlate with the degradation of collagen fibers within the periodontium.
View Article and Find Full Text PDFAirborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease.
Eur Respir Rev
April 2024
School of Pharmacy, Queen's University Belfast, Belfast, UK
Article Synopsis
- Common airborne allergens, like pollen and animal dander, trigger type I allergic disorders in the respiratory system, leading to conditions such as allergic asthma and rhinitis.
- These allergens cause various immune responses, including IgE crosslinking and inflammatory cell infiltration, which can result in airway remodeling and dysfunction.
- The article reviews the role of serine proteases from allergens in promoting allergic reactions and suggests that small-molecule inhibitors might be a potential treatment strategy for allergic airway diseases.
A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice.
Proc Natl Acad Sci U S A
February 2024
Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg 405 30, Sweden.
Efficient removal of fibrillar collagen is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we used mice to further define the mechanism for this collagenolytic process. We show that loss of collagen type-1 (CT1) and increased CT1-fragment levels in expanding SAT are associated with proliferation of resident M2-like macrophages that display increased CD206-mediated engagement in collagen endocytosis compared to chow-fed controls.
View Article and Find Full Text PDFNanoSHP099-Targeted SHP2 Inhibition Boosts Ly6C Monocytes/Macrophages Differentiation to Accelerate Thrombolysis.
Adv Sci (Weinh)
April 2024
Department of Pathology and Pathophysiology, and Department of Respiratory Medicine at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, China.
Article Synopsis
- Tumor-associated thrombus (TAT) significantly contributes to venous thromboembolism, complicating treatment and sometimes resulting in death before the tumor itself can be addressed.
- The study highlights the role of myeloid SHP2 deficiency in enhancing monocyte/macrophage differentiation and promoting thrombus resolution by boosting the activity of enzymes like MMP2/9.
- A novel delivery system called NanoSHP099 was developed, showing improved targeting and thrombolytic effects in cancer research, performing better than regular SHP099 in reducing both tumor size and thrombus burden.
Targeting FGFR3 is a Useful Therapeutic Strategy for Rheumatoid Arthritis Treatment.
Curr Mol Pharmacol
November 2023
Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Background: Rheumatoid arthritis (RA) is a systemic inflammatory disease in which TNF-α plays an important role. Fibroblast growth factor receptor 3 (FGFR3) is reportedly involved in RA by regulating the expression of inflammatory cytokines.
Objective: This study examined the expression profile of FGFR3 in human synovial biopsy tissues and evaluated its gene-silencing effects on behaviors of synovial cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!