Purpose: The IAEA TRS-398 code of practice can be applied for the measurement of absorbed dose to water under reference conditions with an ionization chamber. For protons, the combined relative standard uncertainty on those measurements is less than 2% while for light-ion beams, it is considerably larger, i.e. 3.2%, mainly due to the higher uncertainty contributions for the water to air stopping power ration and the W air-value on the beam quality correction factors kQ,Q . To decrease this uncertainty, a quantification of kQ,Q is proposed using a primary standard level graphite calorimeter. This work includes numerical and experimental determinations of dose conversion factors to derive dose to water from graphite calorimetry. It also reports on the first experimental data obtained with the graphite calorimeter in proton, alpha and carbon ion beams.
Methods: Firstly, the dose conversion has been calculated with by Geant4 Monte-Carlo simulations through the determination of the water to graphite stopping power ratio and the fluence correction factor. The latter factor was also derived by comparison of measured ionization curves in graphite and water. Secondly, kQ,Q was obtained by comparison of the dose response of ionization chambers with that of the calorimeter.
Results: Stopping power ratios are found to vary by no more than 0.35% up to the Bragg peak, while fluence correction factors are shown to increase slightly above unity close to the Bragg peak. The comparison of the calorimeter with ionization chambers is currently under analysis. For the modulated proton beam, preliminary results on W air confirm the value recommended in TRS-398. Data in both the non-modulated proton and light-ion beams indicate higher values but further investigation of heat loss corrections is needed.
Conclusions: The application of graphite calorimetry to proton, alpha and carbon ion beams has been demonstrated successfully. Other experimental campaigns will be held in 2012. This work is supported by the BioWin program of the Wallon Government.
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http://dx.doi.org/10.1118/1.4735204 | DOI Listing |
Nanoscale Horiz
January 2025
Departmento de Fisica, Universidad Técnica Federico Santa María, Av. España 1680, Valparaíso, Chile.
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January 2025
Department of Physics & Astronomy, University of Notre Dame, Notre Dame, 46556, IN, USA. Electronic address:
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July 2024
Faculty of Physics, University of Vienna, 1090 Vienna, Austria.
Thin films of the superconductor YBaCuO (YBCO) were modified by low-energy light-ion irradiation employing collimated or focused He beams, and the long-term stability of irradiation-induced defects was investigated. For films irradiated with collimated beams, the resistance was measured in situ during and after irradiation and analyzed using a phenomenological model. The formation and stability of irradiation-induced defects are highly influenced by temperature.
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November 2023
Department of Medical Physics, Ludwig-Maximilians-Universität München (LMU), Munich, Germany.
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Department of Oncology-Pathology, Karolinska Institutet,17176 Stockholm, Sweden.
The new biological interaction cross-section-based repairable-homologically repairable (RHR) damage formulation for radiation-induced cellular inactivation, repair, misrepair, and apoptosis was applied to optimize radiation therapy. This new formulation implies renewed thinking about biologically optimized radiation therapy, suggesting that most TP53 intact normal tissues are low-dose hypersensitive (LDHS) and low-dose apoptotic (LDA). This generates a fractionation window in LDHS normal tissues, indicating that the maximum dose to organs at risk should be ≤2.
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