Purpose: Effective treatment planning for radiotherapy is dependent on accurate spectra determination; however, direct measurements of spectra arecomplicated by fluence rates that exceed detection system limitations. This work demonstrates the potential to use a Compton scattering technique to measure the spectrum of a 6MV linac. These spectra are further characterized using Monte Carlo (MC) simulations.
Methods: A high-purity germanium detector was used to measure the photon spectrum scattered at35 degrees from the central axis of 3cmx3cm and lOcmxlOcm 6MV fields from a Varian linac. Photons were scattered using aluminum rods positioned at isocenter, and were admitted to the detector through a 30cm-long collimating aperture. The measured Compton-scattered spectra were corrected for background. An MC model of the linac was developed in MCNP5 to calculate central- and off-axis spectra. The model geometry was verified by comparisons with percentage depth-dose and profilemeasurements. The spectroscopic effect of the mean energy, radius, and divergence of the electron beam incident on the target was tested for twofield sizes.
Results: The count rate of the scattered beam increased with field size and scattering rod diameter. Preliminary measurements indicate that the spectrum was shifted to lower energies using this technique; however, the signal-to-noise ratio was poor due to leakage and room scatter. MC simulations demonstrate that the central- and off-axis spectra were sensitive to changes in mean electron energy; however, changes in beam diameter and angular divergence did not substantially affect either the central- or off-axis spectra.
Conclusions: This work demonstrates that the spectrum from a 6MV linac can be measured using Compton spectrometry. Further work is required to increase the signal-to-noise ratio and correct fordetector response. MC simulations indicate that the spectra were sensitive to variations in the parameters used to define the primary electron beam incident on the target.
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http://dx.doi.org/10.1118/1.4734669 | DOI Listing |
Sensors (Basel)
December 2024
Smart Computational Imaging Laboratory (SCILab), School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Lens-free on-chip microscopy (LFOCM) is a powerful computational imaging technology that combines high-throughput capabilities with cost efficiency. However, in LFOCM, the phase recovered by iterative phase retrieval techniques is generally wrapped into the range of -π to π, necessitating phase unwrapping to recover absolute phase distributions. Moreover, this unwrapping process is prone to errors, particularly in areas with large phase gradients or low spatial sampling, due to the absence of reliable initial guesses.
View Article and Find Full Text PDFJ Contemp Brachytherapy
October 2024
Department of Radiation Oncology, East Carolina University, Greenville, North Carolina, USA.
Purpose: To investigate sensitivity of contributing factors to heterogeneity corrections in ocular brachytherapy using iodine-125 (I) Collaborative Ocular Melanoma Study (COMS) plaques.
Material And Methods: Using egs_brachy, Monte Carlo (MC) simulations were performed for I COMS plaques (model: IsoAid IAI-125A). Homogeneous dose (D) was estimated under the American Association of Physicists in Medicine Task Group-43 assumptions, with 85 Gy prescribed to a 5 mm depth.
Alignment of a single-pixel quantum ghost imaging setup is complex and requires extreme precision. Due to misalignment, easily created by human error in the alignment process, reconstructed images are often translated off the central imaging axis. This becomes problematic for intelligent object detection and identification in fast imaging cases, as these algorithms are unable to achieve early image identification.
View Article and Find Full Text PDFJ Magn Reson Imaging
November 2024
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Extremely severe nausea was experienced by four subjects positioned prone on a 7T scanner table with their arm extended overhead for a wrist examination and their head positioned approximately 10-20 cm above the magnet's central axis. Movement through the large static and spatial field gradients of current 7T MRI scanner magnets typically causes mild vestibular activation which is well tolerated by most individuals. However, when positioned off-axis, the head moves through regions of even larger and more rapidly changing magnetic fields which in the current study were sufficient to induce the extremely severe nausea.
View Article and Find Full Text PDFbioRxiv
July 2024
Theoretical Molecular Biophysics Laboratory, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Voltage-gated K channels play central roles in human physiology, both in health and disease. A repertoire of inhibitors that are both potent and specific would therefore be of great value, not only as pharmacological agents but also as research tools. The small molecule RY785 has been described as particularly promising in this regard, as it selectively inhibits channels in the Kv2 subfamily with high potency.
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