AI Article Synopsis
- The study examined how different doses of baclofen affect alcohol dependence among 202 patients over a year.
- Patients were grouped into three dosage categories: low (<90 mg/d), medium (90-150 mg/d), and high (>150 mg/d), with the aim of determining the relationship between these doses and a favorable drinking outcome defined as reduced alcohol consumption.
- Results showed that while medium doses were less effective, both low and high doses improved the chances of achieving a favorable drinking outcome, indicating a U-shaped relationship between baclofen dosage and its effectiveness in reducing alcohol intake.
Article Abstract
Objective: Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence.
Methods: Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient-month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/w for at least 2 consecutive months. We divided the DDB of each patient-month into 3 categories (low dose: <90 mg/d, medium dose: 90-150 mg/d, and high dose: >150 mg/d) and investigated the relationship between reaching a favorable outcome and the concurrent DDB category in a time-varying Cox regression analysis. Hazard ratios (HRs) were adjusted based on age, sex, and initial AWAC.
Results: One hundred forty subjects were followed during at least 1 month. Of these patients, 58 (41%) had a favorable drinking outcome. In comparison to low dose, medium dose was associated with a decreased rate of favorable drinking outcome (HR = 0.42; 95% CI [0.20, 0.88]), whereas no difference was found with high dose (HR = 1.31; 95% CI [0.65, 2.64]).
Conclusion: The relationship between dose of baclofen and favorable drinking outcome was U-shaped, that is, was increased at low and high doses compared to medium doses.
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| http://dx.doi.org/10.1002/hup.2593 | DOI Listing |
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