Screening Evaluation of the Interaction of Linear-Chain or Branched-Chain Peptides with Multilamellar Vesicle, Using Confocal Laser Microscopy.

In the present research, we prepared an acidic liposome as a cell model and used confocal laser microscopy to evaluate its interaction with oligopeptides that had high membrane permeability or affinity. The results showed that, for short peptides of about ten residues, the positive charge peptides interacted with the acidic liposome strongly. For peptides that interacted with the liposome, no difference was found between linear-chain and branched-chain peptides due to their structure.