AI Article Synopsis
- The study aimed to analyze how the drug rE-4, a glucagon-like peptide-1 receptor agonist, is processed in the body of Chinese patients with type 2 diabetes to help tailor their treatment.
- Twelve patients received rE-4 injections and their dosage was adjusted based on glycated albumin levels, while data was analyzed using a two-compartment pharmacokinetic model.
- The findings revealed specific parameters related to the drug's absorption and distribution, highlighting significant variability among individuals but no external factors influenced these parameters significantly.
Article Abstract
Objective: To investigate the population pharmacokinetics of lyophilized recombinant glucagon-like peptide-1 receptor agonist (rE-4) in Chinese patients with type 2 diabetes mellitus (T2DM) for plasma concentration estimation and individualized treatment.
Methods: Twelve patients with T2DM were enrolled to receive subcutaneous injections of rE-4 at 5 µg twice daily for 84 days. Administration dosage was adjusted from 5 µg to 10 µg twice daily at day 29 in case of glycated albumin (GA) ≥ 17%. The population pharmacokinetic model was developed in the nonlinear mixed-effects modeling software NONMEM.
Results: The data were best described by a two-compartment model with first-order absorption and elimination. The outcome parameters were as follows: apparent clearance (CL/F) 6.67 L/h, apparent distribution volume of central compartment (V/F) 19.4 L, absorption rate constant (K) 1.39 h, apparent distribution volume of peripheral compartment (V/F) 22.6 L, intercompartmental clearance (Q/F) 1.28 L/h. The interindividual variabilities for CL/F, V/F, K, and Q/F were 64.4%, 57.7%, 45.5%, and 153.3%, respectively. The intra-individual variability of proportional error model was 41.7%. No covariate was screened out that showed significant influence on the model parameters.
Conclusions: The established two-compartment model with first-order absorption and elimination successfully described the pharmacokinetic characteristics of rE-4 in Chinese patients with T2DM.
.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.5414/CP202973 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Realization of a Half Metal with a Record-High Curie Temperature in Perovskite Oxides.
Adv Mater
April 2022
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing, 100190, China.
Half metals, in which one spin channel is conducting while the other is insulating with an energy gap, are theoretically considered to comprise 100% spin-polarized conducting electrons, and thus have promising applications in high-efficiency magnetic sensors, computer memory, magnetic recording, and so on. However, for practical applications, a high Curie temperature combined with a wide spin energy gap and large magnetization is required. Realizing such a high-performance combination is a key challenge.
View Article and Find Full Text PDFDesigning Multicoordinating Nitronyl Nitroxide Radical Toward Multinuclear Lanthanide Aggregates.
Inorg Chem
January 2020
Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry, College of Chemistry , Nankai University, Tianjin 300071 , China.
Profiting from a multicoordinating nitronyl nitroxide radical, i.e. a functionalized nitronyl nitroxide biradical ligand, a family of novel tetranuclear lanthanide complexes, formulated as [RE(hfac)(NITPhO-3Pybis)] (RE = Gd , Tb , Dy , Ho , and Y ; NITPhO-3Pybis = 5-(3-pyridinyloxy)-1,3-bis(1'-oxyl-3'-oxido-4',4',5',5'-tetramethyl-4,5-hydro-1-imidazol-2-yl)benzene; hfac = hexafluoroacetylacetonate) were successfully constructed and characterized.
View Article and Find Full Text PDFThree Types of Distinguishing l-Alanine-Decorated and Rare-Earth-Incorporated Arsenotungstate Hybrids Prepared in a Facile One-Step Assembly Strategy.
Inorg Chem
March 2019
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering , Henan University, Kaifeng , Henan 475004 , People's Republic of China.
Three kinds of distinguishing ala-decorated RE-incorporated (ala = l-alanine, RE = rare-earth) polytungstoarsenate hybrids containing {AsWO} building blocks [HN(CH)]NaH[EuW(HO)(ala)O(AsWO)]·35HO (1), [HN(CH)]NaH[REW(HO)(ala)O(OH)(AsWO)]·36HO [RE = Gd (2), Tb (3)], and [HN(CH)]Na[REW(HO)(ala)O(OH)(AsWO)]·40HO [RE = Dy (4), Ho (5), Er (6), Yb (7), Lu (8)] were made in a facile one-step assembly strategy. The polyoxoanion skeletons of 1-8 are very similar, and all can be described as two [AsWO] moieties encapsulating an ala-decorated W-O-RE heterometallic cluster ([EuW(HO)(ala)O] for 1, [REW(HO)(ala)O(OH)] for 2-3, and [REW(HO)(ala)O(OH)] for 4-8, resulting in a four-leaf--clover-shaped tetrameric structure; however, the major discrepancy in the ala-decorated W-O-RE heterometallic clusters lies in the number of ala molecules equaling to three, four, and two, which may result from the various coordination geometries of RE ions and the different construction modes of W-O-RE heterometallic clusters. It should be emphasized that the carboxyl groups of ala ligands only coordinate to the W centers in 4-8, while they not only bridge the W centers together but also combine RE ions together in 1-3.
View Article and Find Full Text PDF[Analysis of clinical data, esophageal motility and reflux characteristics in patients with non-erosive reflux disease(NERD) and reflux esophagitis(RE)].
Zhonghua Yi Xue Za Zhi
May 2018
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
To compare the clinical data, esophageal motility and reflux characteristic in patients with non-erosive reflux disease (NERD) and reflux esophagitis (RE). A total of 167 patients of NERD were enrolled in the study[60 males, 107 females, mean age(44.1±13.
View Article and Find Full Text PDFPharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus.
Clin Drug Investig
December 2017
Department of Pharmacy, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Background And Objectives: Recombinant glucagon-like peptide-1 receptor agonist (rE-4) is a glucagon-like peptide-1 receptor agonist, which has the same amino acid sequence to exenatide, except for the C-terminal deamidated. This study assessed the pharmacokinetics and preliminary pharmacodynamics of rE-4, following single and multiple subcutaneous injections in Chinese patients with type 2 diabetes mellitus (T2DM).
Design And Methods: In the randomized, open-label study, Chinese patients with T2DM (n = 36) were randomly assigned to three groups of rE-4 (n = 12), rE-4 with metformin (n = 12) and exenatide (n = 12, as the control group) for 12 weeks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!