Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/ans.14030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Short chain fatty acids mediates complement C1q pathway alleviation of perioperative neurocognitive disorders.
Neuropharmacology
December 2024
Department of Anesthesiology, Hebei Medical University Third Hospital, Shijiazhuang, 050051, Hebei Province, PR China. Electronic address:
Perioperative neurocognitive disorders (PND) is one of the most common postoperative complications, which can lead to a harmful impact on self-dependence, longer hospital stays, increased medical costs, morbidity, and mortality amongst older adults. Microglia can modulate synapse elimination involved in the complement component protein 1q (C1q) pathway to induce cognitive dysfunction, which is significantly improved by short chain fatty acids (SCFAs) treatment. Here we investigate the effects of SCFAs treatment on PND via mediating C1q complement pathway.
View Article and Find Full Text PDFDysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection.
Microbiol Spectr
December 2024
Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.
This study compared intestinal DNA phage dynamics and gut microbiota changes observed at the onset of coronavirus disease 2019 (COVID-19). The study participants included 19 healthy individuals and 19 patients with severe acute respiratory syndrome coronavirus 2 infection. Significant differences were observed in the diversity of the intestinal DNA virome after the onset of COVID-19 compared with that in healthy individuals.
View Article and Find Full Text PDFChinese herbal medicine, Tongxieyaofang, alleviates diarrhea via gut microbiota remodeling: evidence from network pharmacology and full-length 16S rRNA gene sequencing.
Front Cell Infect Microbiol
December 2024
Research and Development Center, Kangpu Pharmaceutical Co., Ltd., Changde, Hunan, China.
Background: Tongxieyaofang (TXYF) was a traditional Chinese medicine (TCM) formula for the treatment of diarrhea with liver stagnation and spleen deficiency syndrome, but the potential targets and mechanisms have not been fully clarified. This study aims to explore the potential mechanisms of TXYF in alleviating diarrhea using network pharmacology and full-length 16S rRNA gene sequencing.
Methods: Network pharmacology was applied to identify bioactive compounds and potential targets involved in the role of TXYF in alleviating diarrhea.
Weichang' an pill alleviates functional dyspepsia through modulating brain-gut peptides and gut microbiota.
J Tradit Chin Med
December 2024
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100010, China.
Article Synopsis
- The study aimed to assess how Weichang'an pill (WCAP) affects functional dyspepsia (FD) in rats, focusing on brain-gut peptides and gut microbiota as potential treatment mechanisms.
- Researchers created an FD rat model and divided the rats into different treatment groups, including those receiving WCAP and a control for comparison, then measured gastrointestinal motility and gut microbiota composition.
- Results showed that WCAP improved FD symptoms by enhancing gastric emptying, regulating brain-gut peptide levels, and restoring gut microbiota balance, suggesting it could be an effective treatment for FD.
Analysis of composition of gut microbial community in a rat model of functional dyspepsia treated with Simo Tang.
J Tradit Chin Med
December 2024
Centralab, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Objective: To investigate composition of gut microbial community in a rat model of functional dyspepsia (FD) and to explore the interventional effects of Simo Tang (, SMT).
Methods: A rat model of FD was established through the tail-clamping stimulation method. The rat model of FD was assessed by the state of rats, their weight, sucrose preference rate, and intestinal propulsion rate.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!