Numerous studies identify that IP-10 and IFN- are involved in leucocyte migration and activation and regarded as promising surrogate biomarkers in human and bovine tuberculosis infection, but there is lack of evidence for IP-10 in nonhuman primates. In this study, we directly determined IP-10 and IFN- levels in plasma from 30 healthy monkeys, 30 monkeys with naturally acquired tuberculosis, 4 monkeys experimentally infected with tuberculosis, and PPD stimulated whole blood of 14 monkeys with naturally acquired tuberculosis by ELISA. Higher plasma levels of IP-10 and IFN- were observed in natural tuberculosis monkeys than in healthy controls. The dynamic changes of plasma IP-10 and IFN- in experimental infections showed consistent representation of a transient increase during the infection period. After PPD stimulation, release of IP-10 and IFN- is significantly induced in natural tuberculosis monkeys, but the stimulation index of IP-10 was significantly lower than IFN-. Further analysis showed that positive correlation between IP-10 and IFN- existed in healthy and tuberculosis monkeys. Our findings support plasma IP-10 and IFN- as biomarkers for monitoring ongoing inflammation of nonhuman primate tuberculosis, and IFN- is a more valuable diagnostic biomarker.
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| http://dx.doi.org/10.1155/2017/5089752 | DOI Listing |
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