Genetic Alterations in Gastric Cancer Associated with Infection.

Front Med (Lausanne)

Programa de Inmunología Molecular Microbiana, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.

Published: May 2017

AI Article Synopsis

  • Gastric cancer is a significant health issue in Mexico, ranking as the fourth leading cause of cancer-related deaths, influenced by both environmental and genetic factors.
  • Recent research has highlighted various genes and molecular mechanisms involved in gastric cancer development, including gene expression patterns, DNA methylation, and inflammatory responses.
  • A number of specific genes have been identified that may play roles in tumor activation or suppression, offering potential for use as biomarkers and targets for future treatments.

Article Abstract

Gastric cancer is a world health problem and depicts the fourth leading mortality cause from malignancy in Mexico. Causation of gastric cancer is not only due to the combined effects of environmental factors and genetic variants. Recent molecular studies have transgressed a number of genes involved in gastric carcinogenesis. The aim of this review is to understand the recent basics of gene expression in the development of the process of gastric carcinogenesis. Genetic variants, polymorphisms, desoxyribonucleic acid methylation, and genes involved in mediating inflammation have been associated with the development of gastric carcinogenesis. Recently, these genes (interleukin 10, Il-17, mucin 1, β-catenin, CDX1, SMAD4, SERPINE1, hypoxia-inducible factor 1 subunit alpha, GSK3β, CDH17, matrix metalloproteinase 7, RUNX3, RASSF1A, TFF1, HAI-2, and COX-2) have been studied in association with oncogenic activation or inactivation of tumor suppressor genes. All these mechanisms have been investigated to elucidate the process of gastric carcinogenesis, as well as their potential use as biomarkers and/or molecular targets to treatment of disease.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411440PMC
http://dx.doi.org/10.3389/fmed.2017.00047DOI Listing

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