Neuroprotective Effect of Extract against Alzheimer's Disease.

Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of A peptide were evaluated in vitro. After 9-month treatment, FDE exhibited multifunctional properties on A-related pathologies, which cleaned A deposits in the brain and decreased A burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PS1 transgenic mice and also promoted A fibrils disaggregation and inhibited neurotoxicity induced by A in SH-SY5Y cells. These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.